Tran Quan Le, Tezuka Yasuhiro, Ueda Jun-ya, Nguyen Nhan Trung, Maruyama Yukiko, Begum Khurshida, Kim Hye-Sook, Wataya Yusuke, Tran Qui Kim, Kadota Shigetoshi
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan.
J Ethnopharmacol. 2003 Jun;86(2-3):249-52. doi: 10.1016/s0378-8741(03)00045-x.
Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC(50) values less than 10 microg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC(50) value of 0.5 microg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
在从越南传统医学中用于治疗疟疾的14种药用植物制备的42种提取物中，发现24种具有抗疟原虫活性，通过抑制耐氯喹恶性疟原虫菌株FCR-3的生长，其半数有效浓度（EC50）值小于10微克/毫升。每种药用植物至少有一种活性提取物。毛叶柯蛇孢的甲醇提取物具有最强的抗疟原虫活性，EC50值为0.5微克/毫升。活性导向分离鉴定出小檗碱为主要活性成分。
