Casini Silvia, Fossi M Cristina, Leonzio Claudio, Renzoni Aristeo
Department of Environmental Science G. Sarfatt, University of Siena, Via Mattioli, 4 53100 Siena, Italy.
Ecotoxicology. 2003 Feb-Aug;12(1-4):297-305. doi: 10.1023/a:1022519214505.
In this review the biochemical, metabolic and toxicological significance of porphyrins in birds is examined, and their use as biomarkers of exposure to xenobiotics and heavy metals is explored. Laboratory studies pinpointing the main classes of compounds that alter porphyrin profiles are described, as well as those which defined the resulting porphyrin profiles and target organs. Field studies in which the biomarker was validated on natural populations of several species of birds are then reviewed. We finally illustrate their potential as a nondestructive biomarker suitable for situations in which destructive sampling of natural populations must be avoided, suggesting the implementation of this approach.
在本综述中，我们研究了卟啉在鸟类中的生化、代谢和毒理学意义，并探讨了它们作为接触外源性物质和重金属生物标志物的用途。描述了确定改变卟啉谱的主要化合物类别的实验室研究，以及那些定义了所得卟啉谱和靶器官的研究。接着回顾了在几种鸟类自然种群中验证该生物标志物的实地研究。我们最后说明了它们作为一种适用于必须避免对自然种群进行破坏性采样情况的非破坏性生物标志物的潜力，并建议实施这种方法。
