Koivisto V A, Nikkilä E A, Akerblom H K
Diabetologia. 1975 Oct;11(5):401-5. doi: 10.1007/BF00429907.
The lipolytic effect of norepinephrine (NE) in adipose tissue in vitro was studied before and after exercise in non-fasted rats with severe, untreated streptozotocin diabetes. It was observed that: 1. NE in increasing concentrations stimulated glycerol release in vitro to an equal extent from the adipose tissue of nondiabetic and diabetic rats. However, the re-esterification of free fatty acids (FFA) in adipose tissue in vitro was decreased by NE in diabetic rats as compared to normal rats. 2. During exercise NE further decreased the re-esterification of FFA in vitro in adipose tissue of diabetic rats. 3. Exercise did not change NE-induced glycerol release in vitro in the adipose tissue of diabetic rats. 4. In diabetic animals the increase in plasma glycerol and FFA during exercise was correlated inversely with the NE-induced release of glycerol and FFA from the adipose tissue of the same animals after exercise. The lipolytic effect of NE is not significantly different in adipose tissue of diabetic and nondiabetic rats. By decreasing the re-esterification of FFA in vitro, NE is probably responsible for the observed increase in the release of FFA in vivo, a likely energy source in severely diabetic animals.
在未禁食的重度未治疗链脲佐菌素糖尿病大鼠运动前后，研究了去甲肾上腺素（NE）对体外脂肪组织的脂解作用。观察到：1. 浓度不断增加的NE在体外同等程度地刺激非糖尿病和糖尿病大鼠脂肪组织释放甘油。然而，与正常大鼠相比，糖尿病大鼠体外脂肪组织中游离脂肪酸（FFA）的再酯化作用被NE降低。2. 运动期间，NE进一步降低了糖尿病大鼠体外脂肪组织中FFA的再酯化作用。3. 运动未改变糖尿病大鼠体外脂肪组织中NE诱导的甘油释放。4. 在糖尿病动物中，运动期间血浆甘油和FFA的增加与运动后同一动物脂肪组织中NE诱导的甘油和FFA释放呈负相关。糖尿病和非糖尿病大鼠脂肪组织中NE的脂解作用无显著差异。通过降低体外FFA的再酯化作用，NE可能是导致体内观察到的FFA释放增加的原因，这可能是重度糖尿病动物的一种能量来源。
