Lopes Heno F, Morrow Jason D, Stojiljkovic Milos P, Goodfriend Theodore L, Egan Brent M
Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Am J Hypertens. 2003 May;16(5 Pt 1):331-6. doi: 10.1016/s0895-7061(03)00041-4.
Oxidative stress emerges as a potential factor in the pathogenesis of hypertension and a common signal transduction mechanism by which various risk factors mediate cardiovascular and renal disease. A greater level of oxidative stress could contribute to higher rates of hypertension and related cardiovascular and renal complications in African Americans than in white Americans. The objective of this study was to compare oxidative stress induced by a standardized episode of acute hyperlipidemia in the two groups. Fifteen African Americans (37 +/- 1 years, 9 women/6 men, body mass index 30 +/- 2 kg/m(2)) and 15 whites (38 +/- 2 years, 9 women/6 men, body mass index 27 +/- 1 kg/m(2)) were evaluated. Acute hyperlipidemia was induced by a 4-h long infusion of Intralipid and heparin. Blood samples were drawn at baseline and after 2 and 4 h of acute hyperlipidemia for nonesterified fatty acids, triglycerides, and F2-isoprostanes, a biomarker of oxidative stress. Plasma nonesterified fatty acids and triglycerides increased significantly and similarly in African Americans and whites after 2 and 4 h of the Intralipid and heparin infusion. Although baseline plasma F2-isoprostanes did not differ between groups, F2-isoprostanes increased more in African Americans than in whites at 2 h (12.2 +/- 2.6 v 5.0 +/- 2.9 pg/mL, P <.05) and 4 h (13.9 +/- 3.1 v 3.0 +/- 3.0 pg/mL, P <.05) of acute hyperlipidemia. The results indicate that acute hyperlipidemia increases F2-isoprostanes more in African Americans than in whites. The findings may have important implications for ethnic differences in the prevalence of hypertension and cardiovascular and renal disease.
氧化应激已成为高血压发病机制中的一个潜在因素，也是各种危险因素介导心血管和肾脏疾病的一种常见信号转导机制。与美国白人相比，非洲裔美国人中更高水平的氧化应激可能导致高血压及相关心血管和肾脏并发症的发生率更高。本研究的目的是比较两组在标准急性高脂血症发作时所诱导的氧化应激情况。对15名非洲裔美国人（年龄37±1岁，9名女性/6名男性，体重指数30±2kg/m²）和15名白人（年龄38±2岁，9名女性/6名男性，体重指数27±1kg/m²）进行了评估。通过静脉输注4小时的英脱利匹特和肝素诱导急性高脂血症。在基线以及急性高脂血症2小时和4小时后采集血样，检测非酯化脂肪酸、甘油三酯以及氧化应激生物标志物F2-异前列腺素。在输注英脱利匹特和肝素2小时和4小时后，非洲裔美国人和白人的血浆非酯化脂肪酸和甘油三酯均显著且相似地升高。尽管两组之间基线血浆F2-异前列腺素无差异，但在急性高脂血症2小时（12.2±2.6对5.0±2.9pg/mL，P<.05）和4小时（13.9±3.1对3.0±3.0pg/mL，P<.05）时，非洲裔美国人的F2-异前列腺素升高幅度大于白人。结果表明，急性高脂血症使非洲裔美国人的F2-异前列腺素升高幅度大于白人。这些发现可能对高血压及心血管和肾脏疾病患病率的种族差异具有重要意义。
