Fouchier Ron A M, Kuiken Thijs, Schutten Martin, van Amerongen Geert, van Doornum Gerard J J, van den Hoogen Bernadette G, Peiris Malik, Lim Wilina, Stöhr Klaus, Osterhaus Albert D M E
Department of Virology, Erasmus Medical Centre, 3015 GE Rotterdam, The Netherlands.
Nature. 2003 May 15;423(6937):240. doi: 10.1038/423240a.
Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques () that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease.
The online version of this article (doi:10.1038/423240a) contains supplementary material, which is available to authorized users.
严重急性呼吸综合征（SARS）最近作为一种新的人类疾病出现，截至2003年5月3日，全球6234例疑似病例中有435例死亡。在此，我们通过对食蟹猴进行实验性感染提供证据，证明新发现的与SARS相关的冠状病毒（SCV）是该疾病的病原体。我们对SARS病因的了解将加速诊断测试、抗病毒疗法和疫苗的开发，并可能为这种新出现的疾病提供更精确的病例定义。
本文的在线版本（doi:10.1038/423240a）包含补充材料，授权用户可获取。
