Courneya Kerry S, Friedenreich Christine M, Sela Rami A, Quinney H Arthur, Rhodes Ryan E, Handman Michael
Faculty of Physical Education, University of Alberta, Alberta, Canada T6G 2H9.
Psychooncology. 2003 Jun;12(4):357-74. doi: 10.1002/pon.658.
Physical exercise has been shown to enhance quality of life (QOL) in cancer survivors using pretest-posttest designs and compared to usual care (i.e. no intervention). In the present study, we conducted a randomized controlled trial to determine if exercise could improve QOL in cancer survivors beyond the known benefits of group psychotherapy (GP). We matched 22 GP classes (N=108) on content and then randomly assigned 11 (n=48) to GP alone and 11 (n=60) to GP plus home-based, moderate-intensity exercise (GP+EX). Participants completed a physical fitness test and QOL measures (e.g. Functional Assessment of Cancer Therapy scales) at the beginning and end of GP classes (about 10 weeks). We had excellent recruitment (81%), retention (89%), and adherence (84%) rates and a modest contamination (22%) rate. Using intention-to-treat repeated measures analyses of variance, we found significant Time by Condition interactions for functional well-being, fatigue, and sum of skinfolds. We also found borderline significant interactions for physical well-being, satisfaction with life, and flexibility. All interactions favored the GP+EX condition. We conclude that a home-based, moderate intensity exercise program may im-prove QOL in cancer survivors beyond the benefits of GP, particularly in relation to physical and functional well-being.
通过前后测试设计，并与常规护理（即无干预）相比，体育锻炼已被证明能提高癌症幸存者的生活质量（QOL）。在本研究中，我们进行了一项随机对照试验，以确定锻炼是否能在团体心理治疗（GP）已知益处的基础上，进一步改善癌症幸存者的生活质量。我们根据内容匹配了22节团体心理治疗课程（N = 108），然后将其中11节（n = 48）随机分配至仅接受团体心理治疗组，另外11节（n = 60）随机分配至团体心理治疗加居家中等强度锻炼组（GP + EX）。参与者在团体心理治疗课程开始和结束时（约10周）完成了体能测试和生活质量测量（如癌症治疗功能评估量表）。我们的招募率（81%）、留存率（89%）和依从率（84%）都很高，而沾染率（22%）适中。通过意向性分析的重复测量方差分析，我们发现功能幸福感、疲劳和皮褶厚度总和在时间与条件上存在显著交互作用。我们还发现身体幸福感、生活满意度和灵活性存在临界显著交互作用。所有交互作用均有利于GP + EX组。我们得出结论，居家中等强度锻炼计划可能会在团体心理治疗的益处基础上，进一步改善癌症幸存者的生活质量，特别是在身体和功能幸福感方面。
