印刷材料和计步器对乳腺癌幸存者身体活动及生活质量影响的随机对照试验

Randomized controlled trial of the effects of print materials and step pedometers on physical activity and quality of life in breast cancer survivors.

作者信息

Vallance Jeffrey K H, Courneya Kerry S, Plotnikoff Ronald C, Yasui Yutaka, Mackey John R

机构信息

Faculty of Physical Education and Recreation, Centre for Health Promotion Studies, School of Public Health, and Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

出版信息

J Clin Oncol. 2007 Jun 10;25(17):2352-9. doi: 10.1200/JCO.2006.07.9988.

DOI:10.1200/JCO.2006.07.9988

PMID:17557948

Abstract

PURPOSE

To determine the effects of breast cancer-specific print materials and step pedometers on physical activity (PA) and quality of life (QoL) in breast cancer survivors.

PATIENTS AND METHODS

Breast cancer survivors (N = 377) were randomly assigned to receive one of the following: a standard public health recommendation for PA, previously developed breast cancer-specific PA print materials, a step pedometer, or a combination of breast cancer-specific print materials and step pedometers. The primary outcome was self-reported moderate/vigorous PA minutes per week. Secondary outcomes were QoL (Functional Assessment of Cancer Therapy-Breast), fatigue, self-reported brisk walking, and objective step counts. Assessments were conducted at baseline and postintervention (12 weeks).

RESULTS

Attrition was 10.3% (39 of 377). On the basis of linear mixed-model analyses, PA increased by 30 minutes/week in the standard recommendation group compared with 70 minutes/week in the print material group (mean difference, 39 minutes/week; 95% CI = -10 to 89; d = 0.25; P = .117), 89 minutes/week in the pedometer group (mean difference, 59 minutes/week; 95% CI, 11 to 108; d = 0.38; P = .017), and 87 minutes/week in the combined group (mean difference, 57 minutes/week; 95% CI, 8 to 106; d = 0.37; P = .022). For brisk walking minutes/week, all three intervention groups reported significantly greater increases than the standard recommendation group. The combined group also reported significantly improved QoL (mean difference, 5.8; 95% CI, 2.0 to 9.6; d = 0.33; P = .003) and reduced fatigue (mean difference, 2.3; 95% CI, 0.0 to 4.7; d = 0.25; P = .052) compared with the standard recommendation group.

CONCLUSION

Breast cancer-specific PA print materials and pedometers may be effective strategies for increasing PA and QoL in breast cancer survivors. A combined approach appears to be optimal.

CLINICAL TRIAL REGISTRATION

ClinicalTrials.gov Identifier NCT00221221

摘要

目的

确定乳腺癌专用印刷材料和计步器对乳腺癌幸存者身体活动（PA）和生活质量（QoL）的影响。

患者与方法

乳腺癌幸存者（N = 377）被随机分配接受以下其中一种：PA的标准公共卫生建议、先前制定的乳腺癌专用PA印刷材料、计步器，或乳腺癌专用印刷材料与计步器的组合。主要结局是自我报告的每周中等强度/剧烈强度PA分钟数。次要结局包括生活质量（癌症治疗功能评估-乳腺癌）、疲劳、自我报告的快走情况以及客观步数。在基线和干预后（12周）进行评估。

结果

失访率为10.3%（377例中的39例）。基于线性混合模型分析，标准建议组的PA每周增加30分钟，而印刷材料组为每周增加70分钟（平均差值为39分钟/周；95%CI = -10至89；d = 0.25；P = 0.117），计步器组为每周增加89分钟（平均差值为59分钟/周；95%CI，11至108；d = 0.38；P = 0.017），联合组为每周增加87分钟（平均差值为57分钟/周；95%CI，8至106；d = 0.37；P = 0.022）。对于每周快走分钟数，所有三个干预组报告的增加量均显著高于标准建议组。与标准建议组相比，联合组还报告生活质量显著改善（平均差值为5.8；95%CI，2.0至9.6；d = 0.33；P = 0.003）且疲劳减轻（平均差值为2.3；95%CI，0.0至4.7；d = 0.25；P = 0.052）。