Narayan S, Ezughah F, Standen G R, Pawade J, Kennedy C T C
Department of Dermatology, Bristol Royal Infirmary, Bristol, UK.
Br J Dermatol. 2003 Apr;148(4):817-20. doi: 10.1046/j.1365-2133.2003.05309.x.
We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with cutaneous infarction and subsequent extensive deep vein thrombosis. The eosinophilia improved dramatically with systemic corticosteroid therapy. A variety of skin disorders have been associated with HES, although there are no previous reports of HES associated with cutaneous infarction. HES is a rare disorder characterized by a sustained overproduction of eosinophils and multisystem disease. The aetiology of the eosinophilia remains uncertain but clonal populations of abnormal T-cells producing interleukin 5 may be implicated.
我们报告一例表现为皮肤梗死及随后发生广泛深静脉血栓形成的特发性嗜酸性粒细胞增多综合征（HES）。全身使用糖皮质激素治疗后，嗜酸性粒细胞增多症显著改善。尽管既往尚无HES与皮肤梗死相关的报道，但已有多种皮肤疾病与HES相关。HES是一种罕见疾病，其特征为嗜酸性粒细胞持续过度生成及多系统疾病。嗜酸性粒细胞增多的病因仍不确定，但可能涉及产生白细胞介素5的异常T细胞克隆群体。
