Ambrus J L, Ambrus C M, Odake K, Mink I B, Shields R, Warner W, Bishop C, Tritsch G L, Golden G, Mittelman A
Ann N Y Acad Sci. 1975 Aug 8;255:435-67. doi: 10.1111/j.1749-6632.1975.tb29250.x.
In red blood cells as well as in platelets there appears to be a decrease in adenine nucleotides during storage under blood bank conditions. This can be decreased by use of anticoagulant preservatives with higher phosphate content than the standard ACD solution, through the addition of adenine and inosine. Maintenance of higher ATP levels appears to be related to longer circulating life span after transfusion into patients in the case of red blood cells but not platelets. Inosine and more alkaline preservative medium also contribute to the maintenance of 2,3-DPG levels in red blood cells, and with it to the maintenance of normal hemoglobin dissociation curves and thus oxygen-carrying capacity. Certain nucleoside analogs may contribute to the preservation of platelets and of whole blood by their platelet-aggregation inhibitory activity. Platelet-aggregation inhibitors may also be useful in preventing thromboembolic episodes with potentially greater safety than anticoagulants.
在血库条件下储存时，红细胞和血小板中的腺嘌呤核苷酸似乎会减少。通过使用磷酸盐含量高于标准ACD溶液的抗凝防腐剂、添加腺嘌呤和肌苷，可以减少这种情况。对于红细胞而言，维持较高的ATP水平似乎与输血后在患者体内更长的循环寿命有关，但对血小板则不然。肌苷和碱性更强的保存介质也有助于维持红细胞中的2,3-DPG水平，进而维持正常的血红蛋白解离曲线以及携氧能力。某些核苷类似物可能因其血小板聚集抑制活性而有助于血小板和全血的保存。血小板聚集抑制剂在预防血栓栓塞事件方面可能也有用，且可能比抗凝剂更安全。
