Averbukh L A
Antibiotiki. 1976 Feb;21(2):169-74.
The study of the process of resistance induction in the cells of lymphadenosis to dipin (subline L-5178/D) and bruneomycin (subline L-5178/B) showed that with increasing of the resistance relation between the drug dose and the antitumor effect gradually faded. It was found that only at the first stages of induction of the resistance increase may be found by comparison of values ED50 and ED70 of the lymphadenosis sensitive strain and its resistant sublines. The probit-analysis method provided registration of the resistance increase also at later stages. In this case the resistance level may be estimated by the slope of the dose-response curve.
对淋巴腺瘤细胞系（L-5178/D亚系）对双嘧啶（dipin）和（L-5178/B亚系）对布鲁诺霉素（bruneomycin）的耐药诱导过程的研究表明，随着耐药性的增加，药物剂量与抗肿瘤效果之间的关系逐渐减弱。发现只有在耐药性诱导的最初阶段，通过比较淋巴腺瘤敏感株及其耐药亚系的ED50和ED70值才能发现耐药性增加。概率分析方法也能在后期记录耐药性增加情况。在这种情况下，耐药水平可通过剂量反应曲线的斜率来估计。
