Minenkova E A, Fomina M M, Evseenko L S
Biol Bull Acad Sci USSR. 1980 Jan-Feb;7(1):40-6.
A cytogenetic analysis of variants of Fisher mouse lymphadenosis L-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin C showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. Cytogenetic and kinetic analyses showed that variants of Fisher lymphadenosis L-5178 resistant to bruneomycin and rubomycin C retain sensitivity to N-nitrosomethylurea (NMU). The activity of NMU in an experiment on resistant substrains of lymphadenosis can serve as a basis for the clinical use of NMU in the treatment of lymphomas resistant to antibiotics.
对费希尔小鼠淋巴腺病L - 5178中对抗肿瘤抗生素布鲁诺霉素和柔红霉素C耐药的变体进行细胞遗传学分析表明，肿瘤细胞群体变化的细胞遗传学特征与耐药性发展的化疗指数相关。细胞遗传学和动力学分析表明，对布鲁诺霉素和柔红霉素C耐药的费希尔淋巴腺病L - 5178变体对N - 亚硝基甲脲（NMU）仍保持敏感性。在淋巴腺病耐药亚系实验中NMU的活性可作为NMU在治疗对抗生素耐药的淋巴瘤临床应用的基础。
