Burrows G E, Way J L
Am J Vet Res. 1977 Feb;38(2):223-7.
The combination of cobalt salts and oxygen with the traditional sodium nitrite-sodium thiosulfate antidote may have value as cyanide antidotes. Results reported previously in mice were extended to sheep in the present experiments. Cobaltous chloride (15 mg/kg of body weight) or oxygen with or without sodium nitrite and sodium thiosulfate were compared with respect to the median lethal dose of oral sodium cyanide. Although cobaltous chloride or oxygen used alone did result in a significant increase in the median lethal dose of sodium cyanide in sheep, the protection was minor compared with the overall protection provided by the classic antidotal combination of sodium nitrite and sodium thiosulfate. Cobaltous chloride combined with sodium nitrite and sodium thiosulfate did not provide any increase in protection more than that observed with sodium nitrite and sodium thiosulfate alone. Oxygen used in combination with sodium nitrite and sodium thiosulfate did significantly increase the protection. However, the increase in protection was not of sufficient magnitude to recommend it as a practicable addition to the present therapeutic regimen.
钴盐与氧气和传统的亚硝酸钠-硫代硫酸钠解毒剂联合使用可能具有作为氰化物解毒剂的价值。先前在小鼠中报道的结果在本实验中扩展到了绵羊。将氯化钴（15毫克/千克体重）或氧气与亚硝酸钠和硫代硫酸钠联合或不联合使用，就口服氰化钠的半数致死剂量进行了比较。尽管单独使用氯化钴或氧气确实使绵羊体内氰化钠的半数致死剂量有显著增加，但与亚硝酸钠和硫代硫酸钠经典解毒组合提供的总体保护相比，这种保护作用较小。氯化钴与亚硝酸钠和硫代硫酸钠联合使用并没有比单独使用亚硝酸钠和硫代硫酸钠观察到的保护作用有任何增加。氧气与亚硝酸钠和硫代硫酸钠联合使用确实显著增加了保护作用。然而，保护作用的增加幅度不足以推荐将其作为当前治疗方案的可行补充。
