Loan R, Siebers R, Fitzharris P, Crane J
Wellington Asthma Research Group, Wellington School of Medicine and Health Sciences, New Zealand.
Indoor Air. 2003 Jun;13(2):92-5.
Exposure to allergens from house dust-mites (Der p 1) and domestic cats (Fel d 1) is associated with symptom severity in atopic subjects with asthma and rhinitis. Assessment of allergen exposure in the domestic environment is normally determined by measurement from a single floor site. We determined the variability of these allergens and protein throughout the whole living room floor area. Dust samples were collected from 1 m2 areas from 16 carpeted living room floors in Wellington, New Zealand, and analyzed for concentrations of Der p 1 and Fel d 1. Mean coefficients of variation for Der p 1 and Fel d 1 were 53.1% (range: 28.5-136.8) and 65.6% (range: 28.5-131.0), respectively. This study has demonstrated a large variation of house dust-mite and cat allergens within living room floors and thus assessment of a single sampling site may not be representative of an individual's exposure risk. House dust-mite and cat allergen levels from the center of the room, in front of a couch or chair, or from a corner of the room are similar to mean levels from the whole room. These sites may thus be representative of the whole living room floor in large-scale epidemiological studies.
接触来自屋尘螨（Der p 1）和家猫（Fel d 1）的过敏原与患有哮喘和鼻炎的特应性受试者的症状严重程度相关。通常通过在室内单一楼层位置进行测量来确定家庭环境中的过敏原暴露情况。我们测定了这些过敏原和蛋白质在整个客厅地面区域的变异性。从新西兰惠灵顿16个铺有地毯的客厅地面的1平方米区域采集灰尘样本，并分析其中Der p 1和Fel d 1的浓度。Der p 1和Fel d 1的平均变异系数分别为53.1%（范围：28.5 - 136.8）和65.6%（范围：28.5 - 131.0）。这项研究表明，客厅地面内屋尘螨和猫过敏原存在很大差异，因此对单个采样点的评估可能无法代表个体的暴露风险。房间中央、沙发或椅子前面或房间角落的屋尘螨和猫过敏原水平与整个房间的平均水平相似。因此，在大规模流行病学研究中，这些位置可能代表整个客厅地面的情况。
