Wilczek J
Arch Immunol Ther Exp (Warsz). 1976;24(2):273-8.
In Part I of this study it was found that slow injection of acetylcholine causes an increase in phosphorolytic activity in the working heart and resting skeletal muscle, and at the same time decreases hydrolytic activity. At present, it is shown that atropine and tubocurarine do not inhibit this activity of acetylcholine, but that it is inhibited by blocking the N1 receptor with hexamethonium. These findings indicate that neither the muscarinic receptor in the heart nor the nicotinic N2 receptor in skeletal muscle take part in regulation of glycogenolysis, which is connected with the action of acetylcholine on the cholinergic N1 receptor. Ganglioplegic compounds stimulate hydrolytic activity (hexamethonium, atropine in large doses).
在本研究的第一部分中发现，缓慢注射乙酰胆碱会使工作心脏和静息骨骼肌中的磷酸解活性增加，同时水解活性降低。目前表明，阿托品和筒箭毒碱不会抑制乙酰胆碱的这种活性，但用六甲铵阻断N1受体会抑制该活性。这些发现表明，心脏中的毒蕈碱受体和骨骼肌中的烟碱型N2受体均不参与糖原分解的调节，糖原分解与乙酰胆碱对胆碱能N1受体的作用有关。神经节阻断化合物会刺激水解活性（六甲铵、大剂量阿托品）。
