Glycogenolysis in the heart and skeletal muscle during stimulation and blocking of cholinergic receptors. III. Action of acetylcholine under conditions of sympathicolysis.

Changes in enzymatic activities in phosphorolytic and hydrolytic glycogenolysis in the working heart and in resting skeletal muscle after intravenous injection of sympathicolytic compounds were studied in vitro. Reserpine, alderline and ligation of the adrenals inhibited the influence of acetylcholine on phosphorylase, Reserpine alone or ligation of the adrenals caused an increase in hydrolytic activity similar to that produced by compounds acting on the ganglia. This confirms the concept according to which the adrenergic system (beta-receptor) inhibits hydrolytic activity during glycogenolysis.