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胆碱能受体刺激与阻断过程中心脏和骨骼肌的糖原分解。III. 交感神经阻滞条件下乙酰胆碱的作用。

Glycogenolysis in the heart and skeletal muscle during stimulation and blocking of cholinergic receptors. III. Action of acetylcholine under conditions of sympathicolysis.

作者信息

Wilczek J

出版信息

Arch Immunol Ther Exp (Warsz). 1976;24(2):279-84.

PMID:5985
Abstract

Changes in enzymatic activities in phosphorolytic and hydrolytic glycogenolysis in the working heart and in resting skeletal muscle after intravenous injection of sympathicolytic compounds were studied in vitro. Reserpine, alderline and ligation of the adrenals inhibited the influence of acetylcholine on phosphorylase, Reserpine alone or ligation of the adrenals caused an increase in hydrolytic activity similar to that produced by compounds acting on the ganglia. This confirms the concept according to which the adrenergic system (beta-receptor) inhibits hydrolytic activity during glycogenolysis.

摘要

在体外研究了静脉注射抗交感神经化合物后，工作心脏和静息骨骼肌中磷酸解和水解糖原分解过程中酶活性的变化。利血平、阿的平以及肾上腺结扎均抑制乙酰胆碱对磷酸化酶的影响。单独使用利血平或肾上腺结扎会导致水解活性增加，这与作用于神经节的化合物所产生的增加相似。这证实了如下概念，即肾上腺素能系统（β受体）在糖原分解过程中抑制水解活性。

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Glycogenolysis in the heart and skeletal muscle during stimulation and blocking of cholinergic receptors. III. Action of acetylcholine under conditions of sympathicolysis.胆碱能受体刺激与阻断过程中心脏和骨骼肌的糖原分解。III. 交感神经阻滞条件下乙酰胆碱的作用。
Arch Immunol Ther Exp (Warsz). 1976;24(2):279-84.
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