Zhang L, Zhang L, Wang S
First Military Medical University, Guangzhou 510515.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1999 Mar;13(1):80-2.
To explore the pathogenic mechanism of hemorrhagic fever with renal syndrome(HFRS).
2-3 days old inbred Balb/C suckling mice were inoculated intracerebrally with tissue suspension of soft palate petechia of HFRS patients and the HFRS virus RNA was tested in brain, lung and kidney tissues of sucking mice by nested PCR.
Some of the mice developed acute disease and died. The autopsy analysis indicated that these mice showed pathological changes in microvascular system and parenchymatous tissues. HFRS virus RNA was detected in their brains, lungs and kidney tissues.
These results indicate that HFRS virus exists in the tissue of petechial hemorrhagic spots on soft palate petechia of HFRS patients.
探讨肾综合征出血热（HFRS）的致病机制。
将2 - 3日龄的近交系Balb/C乳鼠脑内接种HFRS患者软腭瘀点组织悬液，采用巢式PCR检测乳鼠脑、肺和肾组织中的HFRS病毒RNA。
部分小鼠发生急性疾病并死亡。尸检分析表明，这些小鼠的微血管系统和实质组织出现病理变化。在它们的脑、肺和肾组织中检测到HFRS病毒RNA。
这些结果表明HFRS病毒存在于HFRS患者软腭瘀点的瘀斑组织中。
