Yamanouchi T, Domae K, Tanishita O, Takahashi Y, Yamanishi K, Takahashi M, Kurata T
Microbiol Immunol. 1984;28(12):1345-53. doi: 10.1111/j.1348-0421.1984.tb00792.x.
Newborn mice and rats were inoculated intracerebrally (ic) or intraperitoneally (ip) with Hantaan virus (76-118 strain) or HFRS-related virus (B-1 strain). The mortality and the influence on the increase of body weight in newborn mice were higher in the groups infected with the 76-118 strain than in the groups infected with the B-1 strain, while the B-1 strain was more virulent in rats than the 76-118 strain. Virus isolation from rats inoculated with either strain was attempted 7 and 11 weeks after inoculation. Virus could be isolated from various organs of rats infected with the B-1 strain, while it was recovered from only the brain and lungs of rats infected with the 76-118 strain. Viral antigen was readily detected in various organs of rats infected with the B-1 strain, but the amount and distribution of antigens were less in rats infected with the 76-118 strain. Our results suggest that the virulence of HFRS-related virus is variable, depending on the species of infected animals as well as on the virus strains. The virus also persists in the injected animals with high titers of antibodies for at least 11 weeks.
将新生小鼠和大鼠分别通过脑内接种（ic）或腹腔接种（ip）汉坦病毒（76 - 118株）或肾综合征出血热相关病毒（B - 1株）。感染76 - 118株的新生小鼠组的死亡率及对体重增加的影响高于感染B - 1株的组，而B - 1株对大鼠的毒性比76 - 118株更强。在接种后7周和11周尝试从接种任一毒株的大鼠中分离病毒。从感染B - 1株的大鼠的各种器官中均可分离到病毒，而从感染76 - 118株的大鼠中仅在脑和肺中分离到病毒。在感染B - 1株的大鼠的各种器官中很容易检测到病毒抗原，但在感染76 - 118株的大鼠中抗原的量和分布较少。我们的结果表明，肾综合征出血热相关病毒的毒力是可变的，这取决于感染动物的种类以及病毒株。该病毒在注射动物体内也会以高滴度抗体持续存在至少11周。
