Williams Philip G, Luesch Hendrik, Yoshida Wesley Y, Moore Richard E, Paul Valerie J
Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.
J Nat Prod. 2003 May;66(5):595-8. doi: 10.1021/np030011g.
Re-collections of the cyanobacterium Lyngbya sp. have yielded two more members of the lyngbyapeptin and lyngbyabellin families. The gross structures of 15-norlyngbyapeptin A (1) and lyngbyabellin D (3) were deduced through standard 2D NMR techniques, with the absolute configuration of both elucidated through degradation and comparison with commercially available and synthetic standards. Degradation to the alpha-amino acid and NOE correlations determined the absolute and relative configuration of the 4-amino-3-hydroxy-5-methylhexanoic acid unit in 3. Lyngbyabellin D (3) displayed an IC(50) value of 0.1 microM against the KB cell line.
对蓝藻Lyngbya sp.的重新采集又得到了lyngbyapeptin和lyngbyabellin家族的另外两个成员。通过标准二维核磁共振技术推导得出了15-去甲lyngbyapeptin A（1）和lyngbyabellin D（3）的总体结构，通过降解以及与市售和合成标准品比较确定了二者的绝对构型。对α-氨基酸的降解以及NOE相关确定了3中4-氨基-3-羟基-5-甲基己酸单元的绝对和相对构型。Lyngbyabellin D（3）对KB细胞系显示出0.1微摩尔的半数抑制浓度（IC50）值。
