来自圣地亚哥海绵Haliclona lunisimilis的氯化乙炔。

Chlorinated acetylenes from the San Diego sponge Haliclona lunisimilis.

作者信息

De Jesus Roman P, Faulkner D John

机构信息

Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0212, USA.

出版信息

J Nat Prod. 2003 May;66(5):671-4. doi: 10.1021/np020542p.

DOI:10.1021/np020542p

PMID:12762804

Abstract

The sponge Haliclona lunisimilis from Point Loma, California, contained six known chlorinated acetylenes, previously isolated from the dorid nudibranch Diaulula sandiegensis, and three new metabolites, (1Z,3Z)-1-chlorohexadeca-1,3-diene-5,7-diyne-14-ol, (1Z,3E,9Z)-15-acetoxy-1-chlorohexadeca-5,7-diyne-1,3,9-triene, and (1Z,3E)-14-acetoxy-1-chlorohexadeca-1,3-diene-5,7-diyne. The structures of the new compounds were elucidated by interpretation of spectroscopic data. The relationship between the sponge metabolites and the nudibranch metabolites is discussed.

摘要

来自加利福尼亚州洛马角的海绵Haliclona lunisimilis含有六种已知的氯化乙炔，这些物质先前是从多鳃裸鳃亚目动物Diaulula sandiegensis中分离出来的，此外还含有三种新的代谢产物，即(1Z,3Z)-1-氯十六碳-1,3-二烯-5,7-二炔-14-醇、(1Z,3E,9Z)-15-乙酰氧基-1-氯十六碳-5,7-二炔-1,3,9-三烯和(1Z,3E)-14-乙酰氧基-1-氯十六碳-1,3-二烯-5,7-二炔。通过光谱数据解析阐明了这些新化合物的结构，并讨论了海绵代谢产物与裸鳃亚目动物代谢产物之间的关系。