卡拉海绵酰胺A，一种从红海海绵瘘管海绵中分离出的新型细胞毒性聚乙炔酰胺。

Callyspongamide A, a new cytotoxic polyacetylenic amide from the Red Sea sponge Callyspongia fistularis.

作者信息

Youssef Diaa T A, van Soest Rob W M, Fusetani Nobuhiro

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

出版信息

J Nat Prod. 2003 Jun;66(6):861-2. doi: 10.1021/np0205809.

DOI:10.1021/np0205809

PMID:12828476

Abstract

Callyspongamide A (1), a new cytotoxic polyacetylenic amide, has been isolated from the marine sponge Callyspongia fistularis collected in the Red Sea. Callyspongamide A is an amide derivative of a C(17)-polyacetylenic acid and phenethylamine. It represents a new class of secondary metabolites within the family Callyspongiidae. Its structure was determined on the basis of 1D and 2D (COSY, HOHAHA, HMQC, and HMBC) NMR studies and high-resolution mass spectral measurement.

摘要

从红海采集的海棉Callyspongia fistularis中分离出一种新的具有细胞毒性的多炔酰胺——Callispongamide A（1）。Callispongamide A是一种C(17) -多炔酸和苯乙胺的酰胺衍生物。它代表了Callispongiidae科内一类新的次生代谢产物。其结构是基于一维和二维（COSY、HOHAHA、HMQC和HMBC）核磁共振研究以及高分辨率质谱测量确定的。