来自菲律宾海绵双盘海绵属（Diplastrella sp.）的溴化聚乙炔
Brominated polyacetylenes from the Philippines sponge Diplastrella sp.
作者信息
Lerch Melissa L, Harper Mary Kay, Faulkner D John
机构信息
Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093-0212, USA.
出版信息
J Nat Prod. 2003 May;66(5):667-70. doi: 10.1021/np020544+.
Five novel brominated polyacetylenic diols, diplynes A-E (2-6), and three sulfated analogues, diplyne A 1-sulfate (7), diplyne C 1-sulfate (8), and 2-deoxydiplyne D sulfate (9), were isolated from the Philippines sponge Diplastrella sp. by employing bioassay-guided fractionation using the HIV-1 integrase inhibition assay. The novel metabolites were characterized by interpretation of spectroscopic data.
通过使用HIV-1整合酶抑制试验进行生物测定指导的分级分离，从菲律宾海绵双盘海绵属（Diplastrella sp.）中分离出五种新型溴化聚乙炔二醇，双炔A-E（2-6），以及三种硫酸化类似物，双炔A 1-硫酸盐（7）、双炔C 1-硫酸盐（8）和2-脱氧双炔D硫酸盐（9）。通过光谱数据分析对这些新型代谢产物进行了表征。
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