来自密克罗尼西亚海绵Aka sp.的新型倍半萜喹诺醇

New sesquiterpene quinols from a Micronesian sponge, Aka sp.

作者信息

Mukku Venugopal J R V, Edrada Ru A, Schmitz Francis J, Shanks Michelle Kelly, Chaudhuri Babathosh, Fabbro Doriano

机构信息

Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.

出版信息

J Nat Prod. 2003 May;66(5):686-9. doi: 10.1021/np0205506.

DOI:10.1021/np0205506

PMID:12762808

Abstract

Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.

摘要

从密克罗尼西亚联邦雅浦岛采集的一种阿卡属海洋海绵中，分离出了三种新的倍半萜喹诺醇（1、2和5）、两种已知的倍半萜喹诺醇（3和4）以及硫酸哈利斯坦醇（6）。通过光谱数据确定了它们的结构，并对虹吸盘海绵素C（3）的结构进行了修正。硫酸盐3和6可抑制CDK4/细胞周期蛋白D1的复合，而1和4则无此作用。