Fu X, Schmitz F J, Tanner R S, Kelly-Borges M
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
J Nat Prod. 1998 Mar;61(3):384-6. doi: 10.1021/np970453q.
Four new imidazole alkaloids, 2-5, along with the known isonaamidine B (1) were isolated from a Pacific sponge, Leucetta cf. chagosensis, collected from Yap, Federated States of Micronesia. Among these, 4 and 5 are zinc complexes derived from isonaamidine B and isonaamidine D. The structures of the new compounds were elucidated from spectral data. Isonaamidine D (3) showed weakly antifungal activity against Aspergillus niger with MIC = 100 micrograms/mL.
从密克罗尼西亚联邦雅浦岛采集的一种太平洋海绵Leucetta cf. chagosensis中分离出了四种新的咪唑生物碱2 - 5，以及已知的异那米定B（1）。其中，4和5是由异那米定B和异那米定D衍生而来的锌配合物。通过光谱数据阐明了新化合物的结构。异那米定D（3）对黑曲霉显示出微弱的抗真菌活性，最低抑菌浓度（MIC）= 100微克/毫升。
