具有增强神经生长因子活性的海滨马鞭草的甾醇和三萜类成分。

Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.

作者信息

Li Yushan, Ishibashi Masami, Satake Masayuki, Chen Xigui, Oshima Yasukatsu, Ohizumi Yasushi

机构信息

Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Sendai 980-8578, Japan.

出版信息

J Nat Prod. 2003 May;66(5):696-8. doi: 10.1021/np020577p.

DOI:10.1021/np020577p

PMID:12762811

Abstract

Two new sterols, stigmast-5-ene 3beta,4beta,7alpha,22alpha-tetraol (1) and stigmast-5-ene 3beta,7alpha,22alpha-triol (2), were isolated from the aerial parts of a Paraguayan medicinal plant, Verbena littoralis, together with the known compounds ursolic acid (3) and oleanolic acid (4). The structures of 1 and 2 were elucidated by spectroscopic analyses. Compounds 2-4 showed an enhancing activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells.

摘要

从巴拉圭药用植物海滨马鞭草（Verbena littoralis）的地上部分分离出两种新的甾醇，豆甾-5-烯-3β,4β,7α,22α-四醇（1）和豆甾-5-烯-3β,7α,22α-三醇（2），以及已知化合物熊果酸（3）和齐墩果酸（4）。通过光谱分析阐明了1和2的结构。化合物2-4在PC12D细胞中显示出增强神经生长因子（NGF）介导的神经突生长的活性。