State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Testing & Analysis Center, Nanjing Normal University, Nanjing 210023, China.
Molecules. 2018 Oct 10;23(10):2590. doi: 10.3390/molecules23102590.
Three new meliacarpinin-type limonoids, toosendanes A⁻C (1⁻3), along with three, known meliacarpinins (4⁻6) were isolated from the bark of . Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher's method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages.
从. 的树皮中分离得到了三种新的米莱卡品型柠檬苦素，分别为 toosendanes A⁻C（1⁻3），以及三种已知的米莱卡品（4⁻6）。基于详细分析，确定了它们的结构及其绝对构型。这些分析包括高分辨质谱（HRESIMS）和 1D/2D-NMR、改良的 Mosher 法以及电子圆二色性（ECD）。柠檬苦素 2 和 3 对 LPS 激活的 RAW 264.7 巨噬细胞表现出中等抑制活性。
