来自红海海绵Callyspongia属的新细胞毒性C22 - 多炔醇类化合物，卡拉海绵醇A - C。

Callyspongenols A-C, new cytotoxic C22-polyacetylenic alcohols from a red sea sponge, Callyspongia species.

作者信息

Youssef Diaa T A, van Soest Rob W M, Fusetani Nobuhiro

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

出版信息

J Nat Prod. 2003 May;66(5):679-81. doi: 10.1021/np030006c.

DOI:10.1021/np030006c

PMID:12762806

Abstract

Investigation of the organic extract of a Red Sea sponge, Callyspongia sp., resulted in isolation and identification of three new C(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies and mass spectral determinations. Compounds 1-4 showed moderate cytotoxicity against P388 and HeLa cells.

摘要

对红海海绵Callyspongia sp.的有机提取物进行研究，结果分离并鉴定出三种新的C(22) - 多炔醇，即海绵烯醇A - C（1 - 3），以及脱氢异苯并查耳酮醇（4）。通过一维和二维核磁共振研究以及质谱测定确定了1 - 3的结构。化合物1 - 4对P388和HeLa细胞显示出中等程度的细胞毒性。