Baguet J-P, Kingwell B A, Dart A L, Shaw J, Ferrier K E, Jennings G L
Department of Cardiology and Hypertension, University Hospital, Grenoble, France.
J Hum Hypertens. 2003 Jun;17(6):407-12. doi: 10.1038/sj.jhh.1001566.
Increased arterial stiffness is observed in a number of cases. The analysis of the regional functional arterial properties is of interest to determine the role of a given risk factor on the vascular wall and in some diseases such as atherosclerosis. We analysed the pulse wave velocity (PWV) measured by the Doppler method with 2D guidance and its reproducibility in different arterial segments in 15 men with coronary artery disease. Regional Doppler PWV was defined as the distance between the extremities of a given segment divided by the transit time calculated by Doppler. Intra- and interobserver reproducibilities of the Doppler measurements were studied in all of the subjects. The variation coefficients were low, maximum at the level of ascending aorta and minimal at the level of iliac segment. This good reproducibility was validated by the Bland-Altman method. Moreover, using this Doppler technique, we found a progressive increase in PWV from the ascending aorta to the iliac segment. These data demonstrate that noninvasive Doppler analysis is a feasible and reproducible method to determine regional PWV.
在许多病例中都观察到动脉僵硬度增加。分析区域功能性动脉特性对于确定特定风险因素在血管壁以及某些疾病（如动脉粥样硬化）中的作用很有意义。我们分析了15名冠心病男性患者通过二维引导的多普勒方法测量的脉搏波速度（PWV）及其在不同动脉节段的可重复性。区域多普勒PWV定义为给定节段两端之间的距离除以通过多普勒计算的传播时间。在所有受试者中研究了多普勒测量的观察者内和观察者间可重复性。变异系数较低，在升主动脉水平最高，在髂段水平最低。这种良好的可重复性通过Bland-Altman方法得到验证。此外，使用这种多普勒技术，我们发现从升主动脉到髂段PWV逐渐增加。这些数据表明，无创多普勒分析是确定区域PWV的一种可行且可重复的方法。
