Petzoldt D
Br J Vener Dis. 1975 Oct;51(5):305-6. doi: 10.1136/sti.51.5.305.
Animal experiments were performed to determine if a single-dose treatment for acute gonorrhoea with 2 g. spectinomycin could cure a simultaneously acquired syphilis at a very early stage of incubation. 300 treponemes (Nichols stain T. pallidum) were inoculated intratesticularly and 3 days later spectinomycin was administered in a dose which produced spectinomycin serum levels similar to those in patients who had received a single oral dose of 2 g. This dosage of spectinomycin did not prevent the development of syphilitic orchitis or reactivity to the FTA-ABS test, but it prolonged the subclinical incubation period.
进行动物实验以确定用2克大观霉素单剂量治疗急性淋病是否能治愈同时感染的处于潜伏期极早期的梅毒。将300个梅毒螺旋体（Nichols株梅毒螺旋体）接种到睾丸内，3天后给予大观霉素，其剂量能使血清大观霉素水平与单次口服2克大观霉素的患者相似。该剂量的大观霉素不能预防梅毒性睾丸炎的发生或FTA - ABS试验的反应性，但可延长亚临床潜伏期。
