Tight R R, White A C
Br J Vener Dis. 1980 Oct;56(5):291-6. doi: 10.1136/sti.56.5.291.
The quantitative microhaemagglutination assay for Treponema pallidum antibodies (MHA-TP) was studies in 52 untreated and treated rabbits with experimental syphilis. Rabbits with incubating experimental syphilis were cured or inadequately treated with penicillin G and some cured rabbits were later reinfected. MHA-TP conversion occurred within 45 days in untreated rabbits. Titres reached peak levels about four months after inoculation and remained relatively high for up to two years. The quantitative MHA-TP test differentiated between rabbits cured of experimental incubating syphilis and those untreated and inadequately treated. MHA-TP titres decreased after treatment given six or 12 months after inoculation but reversion did not occur. MHA-TP conversion or significant increases in titre occurred as soon as seven days after reinfection and preceded corresponding changes in a quantitative non-treponemal test. The MHA-TP is useful as a screening test for treponemal antibodies in rabbits. The quantitative MHA-TP in humans after treatment for syphilis and reinfection deserves further study.
对52只未经治疗和经过治疗的实验性梅毒兔进行了梅毒螺旋体抗体微量血凝定量试验（MHA-TP）研究。患有潜伏性实验性梅毒的兔子用青霉素G进行了治愈或治疗不充分，并且一些治愈的兔子后来再次感染。未经治疗的兔子在45天内出现MHA-TP转化。滴度在接种后约四个月达到峰值水平，并在长达两年的时间内保持相对较高。定量MHA-TP试验区分了治愈潜伏性实验性梅毒的兔子与未经治疗和治疗不充分的兔子。在接种后6个月或12个月给予治疗后，MHA-TP滴度下降，但未出现逆转。再次感染后7天即出现MHA-TP转化或滴度显著升高，且先于定量非梅毒螺旋体试验的相应变化。MHA-TP可用作兔梅毒螺旋体抗体的筛查试验。梅毒治疗和再次感染后人体的定量MHA-TP值得进一步研究。
