Gale Catharine R, Hall Nigel F, Phillips David I W, Martyn Christopher N
Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2461-5. doi: 10.1167/iovs.02-0929.
To investigate the relation between plasma concentrations of lutein and zeaxanthin and age-related macular degeneration in a group of elderly men and women.
The Wisconsin Age-Related Maculopathy Grading System was used to grade features of early and late macular degeneration in 380 men and women, aged 66 to 75 years, from Sheffield, United Kingdom. Fasting blood samples were taken to assess plasma concentrations of lutein and zeaxanthin.
Risk of age-related macular degeneration (early or late) was significantly higher in people with lower plasma concentrations of zeaxanthin. Compared with those whose plasma concentrations of zeaxanthin were in the highest third of the distribution, people whose plasma concentration was in the lowest third had an odds ratio for risk of age-related macular degeneration of 2.0 (95% confidence interval [CI] 1.0-4.1), after adjustment for age and other risk factors. Risk of age-related macular degeneration was increased in people with the lowest plasma concentrations of lutein plus zeaxanthin (odds ratio [OR] 1.9, 95% CI 0.9-3.5) and in those with the lowest concentrations of lutein (OR 1.7, 95% CI 0.9-3.3), but neither of these relations was statistically significant.
These findings provide support for the view that zeaxanthin may protect against age-related macular degeneration.
在一组老年男性和女性中研究叶黄素和玉米黄质的血浆浓度与年龄相关性黄斑变性之间的关系。
采用威斯康星年龄相关性黄斑病变分级系统，对来自英国谢菲尔德的380名年龄在66至75岁之间的男性和女性的早期和晚期黄斑变性特征进行分级。采集空腹血样以评估叶黄素和玉米黄质的血浆浓度。
玉米黄质血浆浓度较低的人群发生年龄相关性黄斑变性（早期或晚期）的风险显著更高。与血浆玉米黄质浓度处于分布最高三分位的人群相比，血浆浓度处于最低三分位的人群在调整年龄和其他风险因素后，发生年龄相关性黄斑变性风险的比值比为2.0（95%置信区间[CI] 1.0 - 4.1）。叶黄素加玉米黄质血浆浓度最低的人群（比值比[OR] 1.9，95% CI 0.9 - 3.5）以及叶黄素浓度最低的人群（OR 1.7，95% CI 0.9 - 3.3）发生年龄相关性黄斑变性的风险增加，但这些关系均无统计学意义。
这些发现支持了玉米黄质可能预防年龄相关性黄斑变性的观点。
