De Backer D
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.
Minerva Anestesiol. 2003 Apr;69(4):281-4.
The detection of tissue hypoxia and its correction is one of the aim of the hemodynamic monitoring. Classical hemodynamic variable often fail to achieve this goal. Lactate measurements may be a good indicator of tissue hypoxia. Selected review of the articles on lactate in critically ill patients. Tissue hypoxia is associated with an increase in blood lactate levels. However lactate can also be produced in aerobic conditions, in inflammated tissues, and lactate clearance is often decreased in critically ill patients. Whatever its origin, blood lactate levels have a strong predictive value. The interpretation of blood lactate levels is difficult. Nevertheless, monitoring blood lactate levels can be useful to detect tissue hypoxia and to monitor the effects of therapy.
组织缺氧的检测及其纠正措施是血流动力学监测的目标之一。传统的血流动力学变量往往无法实现这一目标。乳酸测量可能是组织缺氧的一个良好指标。对有关危重症患者乳酸的文章进行的选定综述。组织缺氧与血乳酸水平升高有关。然而，乳酸也可在有氧条件下、在炎症组织中产生，并且危重症患者的乳酸清除率通常会降低。无论其来源如何，血乳酸水平都具有很强的预测价值。血乳酸水平的解读很困难。尽管如此，监测血乳酸水平对于检测组织缺氧和监测治疗效果可能是有用的。
