Stacpoole P W
Department of Medicine, University of Florida College of Medicine, Gainesville.
Endocrinol Metab Clin North Am. 1993 Jun;22(2):221-45.
Lactic acidosis is the most common metabolic acidosis. At clinical presentation, several causes usually can be identified. The liver is a major site of removal of lactate and hydrogen ions, and abnormalities in the aerobic metabolism of lactate by mitochondria in hepatocytes and other cells may contribute to many clinical conditions in which overproduction and underuse of lactate occur. To date, no therapy specifically designed to lower arterial blood lactate levels has reduced mortality significantly. Prompt recognition and treatment of the underlying causes of lactic acidosis remain the cornerstone of treatment.
乳酸性酸中毒是最常见的代谢性酸中毒。在临床表现时，通常可以确定几种病因。肝脏是清除乳酸和氢离子的主要场所，肝细胞和其他细胞中线粒体对乳酸的有氧代谢异常可能导致许多出现乳酸产生过多和利用不足的临床情况。迄今为止，尚无专门设计用于降低动脉血乳酸水平的疗法能显著降低死亡率。迅速识别和治疗乳酸性酸中毒的潜在病因仍然是治疗的基石。
