Marine natural products as lead anti-HIV agents.

作者信息

Gochfeld D J, El Sayed K A, Yousaf M, Hu J F, Bartyzel P, Dunbar D C, Wilkins S P, Zjawiony J K, Schinazi R F, Schlueter Wirtz S, Tharnish P M, Hamann M T

机构信息

Department of Pharmacognosy and the National Center for Natural Products Research, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA.

出版信息

Mini Rev Med Chem. 2003 Aug;3(5):401-24. doi: 10.2174/1389557033487962.

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.