Peck R M, Tan T K, Peck E B
Cancer Res. 1976 Jul;36(7 PT 1):2423-7.
Simple alkylating derivatives of polycyclic aromatic hydrocarbons have been found to be much more carcinogenic in the Strain A mouse than are the parent hydrocarbons. It has also been shown that the carcinogenicity of these halomethyl hydrocarbons is not a function of the first-order solvolysis rate. The acridine antitumor agent and mutagen ICR 170, 2-methoxy-6-chloro-9-[3-(ethyl-2-chloroethyl)aminopropylamino]acridine dihydrochloride, has been shown to be a potent carcinogen in the same system when administered i.v., superseding data in the literature indicating inactivity when the drug is administered i.p. Stimulation of the immune system has been shown to have a marked inhibitory effect on the carcinogenic activity of this compound.
已发现多环芳烃的简单烷基化衍生物在A系小鼠中比其母体烃类具有更强的致癌性。还表明这些卤代甲基烃的致癌性与一级溶剂分解速率无关。吖啶类抗肿瘤药和诱变剂ICR 170，即2-甲氧基-6-氯-9-[3-(乙基-2-氯乙基)氨基丙基氨基]吖啶二盐酸盐，已证明静脉注射时在同一系统中是一种强效致癌物，推翻了文献中关于腹腔注射该药物无活性的数据。已表明刺激免疫系统对该化合物的致癌活性有显著抑制作用。
