Liu Tao, Yang Pingchang, Wang Binquan, Huangfu Hui, Zhang Nianzu, Xia Lijun
Department of Otorhinolaryngology, First Hospital, Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2002 Aug;37(4):264-6.
To study the barrier role of staphylococcal enterotoxin B (SEB) in rabbit maxillary sinus mucosa.
Rabbit maxillary sinus mucosal membrane was dissected under a surgical microscope. The short-circuit current (Isc), conductance (G) and its permeability to horseradish peroxidase (HRP) were evaluated by employing Ussing chamber technique.
The stimulation of SEB enhanced Isc, G and its permeability to HRP of sinus epithelial barrier. The same results were obtained by applying tumor necrosis factor alpha (TNF-alpha) to rabbit maxillary sinus. Increase in TNF-alpha level in sinus mucosa was observed by the stimulation of SEB. Those pathophysiological abnormalities of sinus mucosa were abolished by pretreatment with anti-TNF-alpha antibody.
The SEB has potential effects on rabbit maxillary sinus mucosal barrier, activates the immune cells in the mucosa, and plays certain roles in maxillary sinusitis.
研究葡萄球菌肠毒素B（SEB）在兔上颌窦黏膜中的屏障作用。
在手术显微镜下解剖兔上颌窦黏膜。采用Ussing chamber技术评估短路电流（Isc）、电导（G）及其对辣根过氧化物酶（HRP）的通透性。
SEB刺激可增强窦上皮屏障的Isc、G及其对HRP的通透性。对兔上颌窦应用肿瘤坏死因子α（TNF-α）也得到了相同结果。SEB刺激可观察到窦黏膜中TNF-α水平升高。用抗TNF-α抗体预处理可消除窦黏膜的那些病理生理异常。
SEB对兔上颌窦黏膜屏障有潜在影响，激活黏膜中的免疫细胞，并在上颌窦炎中起一定作用。
