Wang Weiguo, Xu Rong, Yao Maojun
Department of Otorhinolaryngology, Overseas Chinese Federation Hospital of Shandong, Zibo 255031, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2002 Aug;37(4):274-6.
To explore the effect of treatment on sudden deafness at ultra-early stage and the influence on Malonyldialdehyde (MDA) and superoxide dismutase(SOD) of serum.
One hundred and forty-seven cases of sudden deafness (168 ears) from July 1995 to June 2001 were divided into three groups, 29 cases (36 ears) in group I treated within 6 hours after deafness, 55 cases(63 ears) in group II treated within 15 days after deafness, and 63 cases (69 ears) in group III treatment after 15 days after deafness. Total cases were treated with medicine and hyperbaric oxygen and the volume of SOD and MDA of serum were observed at the same time. There were 30 healthy volunteers as control group.
In the group I, the hearing threshold was recovered in 18 ears, significant improved in 9 ears, improved in 7 ears and not changed in 2 ears after treatment. In the group II, the hearing threshold was recovered in 11 ears, significant improved in 16 ears, improved in 15 ears and no changed in 21 ears after treatment. In the group III, the hearing threshold was recovered in 14 ears, significant improved in 20 ears, improved in 13 ears and no changed in 22 ears after treatment. There was a significant difference in improved level of hearing between the group I and group II. (chi 2 = 9.90, P < 0.01) and between group I and group III (chi 2 = 9.30, P < 0.01). There was no significant difference between group II and group III (chi 2 = 0.03, P > 0.01).
The treatment on sudden deafness in ultra-early stage is very important. The use of free radical scavenger early can protect audio nerve.
探讨超早期治疗对突发性聋的疗效及对血清丙二醛（MDA）和超氧化物歧化酶（SOD）的影响。
将1995年7月至2001年6月收治的147例突发性聋患者（168耳）分为三组，Ⅰ组29例（36耳），于耳聋后6小时内开始治疗；Ⅱ组55例（63耳），于耳聋后15天内开始治疗；Ⅲ组63例（69耳），于耳聋后15天以后开始治疗。全部病例均采用药物及高压氧治疗，同时观察血清SOD及MDA含量。另选30例健康志愿者作为对照组。
Ⅰ组治疗后，听力阈值恢复18耳，显效9耳，有效7耳，无效2耳；Ⅱ组治疗后，听力阈值恢复11耳，显效16耳，有效15耳，无效21耳；Ⅲ组治疗后，听力阈值恢复14耳，显效20耳，有效13耳，无效22耳。Ⅰ组与Ⅱ组、Ⅰ组与Ⅲ组治疗后听力改善程度差异有显著性（χ2分别为9.90、9.30，P均<0.01）；Ⅱ组与Ⅲ组治疗后听力改善程度差异无显著性（χ2=0.03，P>0.01）。
突发性聋超早期治疗十分重要，早期应用自由基清除剂可保护听神经。
