Liu Yangyun, Sun Dajiang, Shao Shan, Jiang Wen, Sun Zhengliang, Li Zhengxian
Department of Otolaryngology Head and Neck Surgery, No. 163 Hospital of PLA, Changsha 410003, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Oct;24(19):890-4.
To investigate the effect of hyperbaric oxygen therapy to different degrees of hearing loss and different types of threshold curve in sudden deafness patients, and establish a personalized therapy, so as to promote clinical effect to sudden deafness.
One hundred and twenty cases were divided into two groups respectively (each group 60 cases). Drug treatment had been used in group A for two weeks. The patients in group B received drug treatment combined with hyperbaric oxygen therapy for two weeks. According to the different degrees of hearing loss and the types of audiogram in two groups, the statistical analysis to the difference of hyperbaric oxygen therapeutic effect was done.
The effective rates was statistically different (chi2 = 8.044, P < 0.01) between group A (60.00%, 36/60) and group B (83.33%, 50/60). There was no statistical difference between two treatment program in mild and the profound deafness patients. The statistical difference could been found between moderate and the severe deafness, the value of chi2 and p were 4.969, 5.560 and 0.040, 0.035, respectively. In group A, the statistical difference could only been found between mild and the profound deafness patients (chi2 = 6.739, P < 0.05). In group B, the statistical difference could been found in mild and the profound deafness, the moderate and the profound deafness, the severe and the profound deafness patients. The value of chi2 were 11.500, 15.058,10.221 and P < 0.01 respectively. The effective rates was no statistical difference in two treatment programs in the upsloping audiogram and the profound deafness. The statistical difference could been found between the downsloping and the flat audiogram, with the value of chi2 and p were 5.144 and 5.969, P < 0.05, respectively. In group A, the statistical difference could been found between the ascending and descending audiogram, the ascending and the flat audiogram,the ascending type and the profound deafness. The value of chi2 were 6.188, 7.247, 8.082 and P < 0.05, respectively. No statistical difference could been found among the other types of audiogram. In group B, no statistical difference could been found among all types of audiogram.
The effect of hyperbaric oxygen therapy varies with degree of hearing loss and audiogram type. Drug treatment combined with HBOT can promote clinical effect for patients in moderate deafness and severe deafness, the descending and flat type of audiogram.
探讨高压氧治疗对突发性聋患者不同程度听力损失及不同类型听阈曲线的影响，制定个性化治疗方案，以提高突发性聋的临床疗效。
将120例患者分为两组（每组60例）。A组采用药物治疗2周。B组采用药物联合高压氧治疗2周。根据两组患者听力损失程度及听力图类型，对高压氧治疗效果的差异进行统计学分析。
A组（60.00%，36/60）与B组（83.33%，50/60）有效率差异有统计学意义（χ2 = 8.044，P < 0.01）。轻度和重度聋患者两种治疗方案之间无统计学差异。中度和重度聋患者之间存在统计学差异，χ2值和P值分别为4.969、5.560和0.040、0.035。A组中，仅轻度和重度聋患者之间存在统计学差异（χ2 = 6.739，P < 0.05）。B组中，轻度和重度聋、中度和重度聋、重度和重度聋患者之间存在统计学差异。χ2值分别为11.500、15.058、10.221，P均< 0.01。上升型听力图和重度聋患者两种治疗方案的有效率无统计学差异。下降型和平坦型听力图之间存在统计学差异，χ2值和P值分别为5.144和5.969，P < 0.05。A组中，上升型与下降型听力图、上升型与平坦型听力图、上升型与重度聋之间存在统计学差异。χ2值分别为6.188、7.247、8.082，P均< 0.05。其他类型听力图之间无统计学差异。B组中，所有类型听力图之间均无统计学差异。
高压氧治疗效果因听力损失程度和听力图类型而异。药物治疗联合高压氧治疗可提高中度聋、重度聋、下降型和平坦型听力图患者的临床疗效。
