Kent Jennifer R, Kang Wen, Miller Cathie G, Fraser Nigel W
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.
J Neurovirol. 2003 Jun;9(3):285-90. doi: 10.1080/13550280390200994.
A major area of interest in the study of herpes simplex virus type 1 (HSV-1) involves the persistence of the virus within a latent state in neuronal cells of infected humans. The latency-associated transcripts (LATs) are believed to play a key role during HSV-1 latency. This review will discuss the most recent findings on the involvement of the LAT region with apoptotic pathways and how this relates to other potential functions of the LATs.
1型单纯疱疹病毒（HSV-1）研究中一个主要的关注领域涉及该病毒在受感染人类神经元细胞内以潜伏状态持续存在。潜伏相关转录本（LATs）被认为在HSV-1潜伏期间发挥关键作用。本综述将讨论关于LAT区域参与凋亡途径的最新发现，以及这与LATs的其他潜在功能有何关联。
