Hay Stewart, Kannourakis George
The Fiona Elsey Cancer Research Laboratory, Cancer Research Centre, School of Science, University of Ballarat, St John of God Hospital, 1002 Mair Street, Ballarat, Victoria 3350, Australia1.
J Gen Virol. 2002 Jul;83(Pt 7):1547-1564. doi: 10.1099/0022-1317-83-7-1547.
Many viruses have as part of their arsenal the ability to modulate the apoptotic pathways of the host. It is counter-intuitive that such simple organisms would be efficient at regulating this the most crucial pathway within the host, given the relative complexity of the host cells. Yet, viruses have the potential to initiate or stay the onset of programmed cell death through the manipulation of a variety of key apoptotic proteins. It is the intention of this review to provide an overview of viral gene products that are able to promote or inhibit apoptotic death of the host cell and to discuss their mechanisms of action. It is not until recently that the depth at which viruses exploit the apoptotic pathways of their host has been seen. This understanding may provide a great opportunity for future therapeutic ventures.
许多病毒具备调控宿主细胞凋亡途径的能力，这是它们的“武器库”的一部分。鉴于宿主细胞相对复杂，如此简单的生物体竟能高效调控宿主细胞内这一至关重要的途径，这有悖于直觉。然而，病毒有能力通过操纵多种关键凋亡蛋白来启动或延缓程序性细胞死亡的发生。本综述旨在概述能够促进或抑制宿主细胞凋亡死亡的病毒基因产物，并探讨其作用机制。直到最近，人们才认识到病毒利用宿主凋亡途径的深度。这种认识可能为未来的治疗探索提供绝佳机会。
