原发性胆汁性肝硬化患者淋巴细胞对大鼠肝线粒体的损伤作用。
Injurious effect on rat liver mitochondria by lymphocytes from patients with primary biliary cirrhosis.
作者信息
Bootello A, Fernandez-Cruz E, Escartin P, Blanco M F, Gosalvez M, Segovia De Arana J M
出版信息
Clin Exp Immunol. 1976 May;24(2):374-7.
Lymphocytes from primary biliary cirrhosis (PBC) patients were shown to have an injurious effect on rat liver mitochondria, as was demonstrated by the inhibition of mitochondrial respiratory control by these cells. The incubation of the PBC patients' lymphocytes with isolated rat liver mitochondria produced a significant inhibition of mitochondrial respiration in the presence of ADP. However, no significant effect on respiration was seen with control lymphocytes of normal persons or with lymphocytes from patients with alcoholic cirrhosis and miscellaneous liver diseases. The results suggest that this injurious effect of PBC lymphocytes on mitochondria might be a consequence of sensitization in vivo of the PBC patients' lymphocytes by the mitochondrial antigens.
原发性胆汁性肝硬化（PBC）患者的淋巴细胞对大鼠肝线粒体具有损伤作用，这些细胞对线粒体呼吸控制的抑制作用证明了这一点。将PBC患者的淋巴细胞与分离的大鼠肝线粒体一起孵育，在有二磷酸腺苷（ADP）存在的情况下，线粒体呼吸受到显著抑制。然而，正常人的对照淋巴细胞以及酒精性肝硬化和其他肝病患者的淋巴细胞对呼吸没有显著影响。结果表明，PBC淋巴细胞对线粒体的这种损伤作用可能是PBC患者的淋巴细胞在体内被线粒体抗原致敏的结果。
Zotero 插件