Lingappa Jairam R, Al-Rabeah Abdullah M, Hajjeh Rana, Mustafa Tajammal, Fatani Adel, Al-Bassam Tami, Badukhan Amira, Turkistani Abdulhafiz, Makki Sahar, Al-Hamdan Nassen, Al-Jeffri Mohamed, Al Mazrou Yaqoub, Perkins Bradley A, Popovic Tonja, Mayer Leonard W, Rosenstein Nancy E
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2003 Jun;9(6):665-71. doi: 10.3201/eid0906.020565.
An outbreak of serogroup W-135 meningococcal disease occurred during the 2000 Hajj in Saudi Arabia. Disease was reported worldwide in Hajj pilgrims and their close contacts; however, most cases were identified in Saudi Arabia. Trends in Saudi meningococcal disease were evaluated and the epidemiology of Saudi cases from this outbreak described. Saudi national meningococcal disease incidence data for 1990 to 2000 were reviewed; cases from January 24 to June 5, 2000, were retrospectively reviewed. The 2000 Hajj outbreak consisted of distinct serogroup A and serogroup W-135 outbreaks. Of 253 identified cases in Saudi Arabia, 161 (64%) had serogroup identification; serogroups W-135 and A caused 93 (37%) and 60 (24%) cases with attack rates of 9 and 6 cases per 100,000 population, respectively. The 2000 Hajj outbreak was the first large serogroup W-135 meningococcal disease outbreak identified worldwide. Enhanced surveillance for serogroup W-135, especially in Africa, is essential to control this emerging epidemic disease.
2000年沙特阿拉伯朝觐期间发生了W-135群脑膜炎球菌病疫情。该病在朝觐者及其密切接触者中向全球报告；然而，大多数病例在沙特阿拉伯被确认。评估了沙特脑膜炎球菌病的发病趋势，并描述了此次疫情中沙特病例的流行病学情况。回顾了1990年至2000年沙特国家脑膜炎球菌病发病率数据；对2000年1月24日至6月5日的病例进行了回顾性分析。2000年朝觐疫情由不同的A群和W-135群疫情组成。在沙特阿拉伯确诊的253例病例中，161例（64%）进行了血清群鉴定；W-135群和A群分别导致93例（37%）和60例（24%）病例，发病率分别为每10万人口9例和6例。2000年朝觐疫情是全球首次确认的大规模W-135群脑膜炎球菌病疫情。加强对W-135群的监测，尤其是在非洲，对于控制这种新出现的流行病至关重要。
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