Roberts-Thomson I C, Stevens D P, Mahmoud A A, Warren K S
Gastroenterology. 1976 Jul;71(1):57-61.
An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spontaneous resolution of infection occurred in most mice after 21 to 28 days. When compared to uninfected controls, Giardia-infected mice had significant impairment of weight gain and a significant reduction in the villus to crypt ratio of jejunal mucosa. Although maximal trophozoite and cyst counts were independent of the size of the cyst inoculum, those mice receiving inoculations of larger numbers of cysts showed earlier attainment of maximal counts, greater impariment of weight gain, and earlier and more severe small bowel changes than mice receiving inoculations of smaller numbers of cysts. This model offers unique opportunities for study of this poorly understood gastrointestinal parasite.
利用鼠贾第虫在瑞士白化小鼠中建立了贾第虫病动物模型。经食管接种鼠贾第虫包囊可引起可重复的感染模式，滋养体和包囊计数在包囊接种后第5至14天达到最大值，此后逐渐下降。大多数小鼠在21至28天后感染自行消退。与未感染的对照组相比，感染贾第虫的小鼠体重增加明显受损，空肠黏膜绒毛与隐窝比值显著降低。尽管最大滋养体和包囊计数与包囊接种量无关，但接种较多包囊的小鼠比接种较少包囊的小鼠更早达到最大计数、体重增加受损更严重，小肠变化更早且更严重。该模型为研究这种了解甚少的胃肠道寄生虫提供了独特的机会。
