Roberts-Thomson I C, Grove D I, Stevens D P, Warren K S
Gut. 1976 Dec;17(12):953-8. doi: 10.1136/gut.17.12.953.
The interaction of the intestinal phases of Giardia muris and Trichinella spiralis was investigated in Swiss albino mice. Intraoesophageal inoculation of G. muris cysts seven days before, or seven days after, similar inoculation of T. spiralis larvae resulted in significant reduction in the numbers of Giardia trophozoites in small bowel and Giardia cysts in stools. This effect was not observed when G. muris cysts were administered after resolution of the intestinal phase of trichinosis. Giardiasis had no effect on trichinosis as assessed by numbers of adult worms in small bowel and larvae in skeletal muscles. Studies of small bowel morphology showed that the intestinal phase of trichinosis was associated with increased numbers of inflammatory cells in the lamina propria, a significant increase in Paneth cells in crypts, and a marked reduction in the villus:crypt ratio of jejunum. These observations suggest that the intestinal phase of trichinosis induced environmental changes in small bowel, perhaps related to inflammation, which resulted in suppression of proliferation of Giardia trophozoites.
在瑞士白化小鼠中研究了鼠贾第虫和旋毛虫肠道阶段的相互作用。在接种旋毛虫幼虫前7天或接种后7天经食管接种鼠贾第虫囊肿，可使小肠中鼠贾第虫滋养体数量和粪便中鼠贾第虫囊肿数量显著减少。当旋毛虫病肠道阶段消退后给予鼠贾第虫囊肿时，未观察到这种效应。通过小肠中成虫数量和骨骼肌中幼虫数量评估，贾第虫病对旋毛虫病没有影响。小肠形态学研究表明，旋毛虫病的肠道阶段与固有层炎症细胞数量增加、隐窝中潘氏细胞显著增多以及空肠绒毛与隐窝比值明显降低有关。这些观察结果表明，旋毛虫病的肠道阶段引起小肠环境变化，可能与炎症有关，从而导致鼠贾第虫滋养体增殖受到抑制。
