Mark Kenneth A, Sparacio Rose Marie, Voigt Audra, Marenus Kenneth, Sarnoff Deborah S
Department of Dermatology, New York University School of Medicine, New York, USA.
Dermatol Surg. 2003 Jun;29(6):600-4. doi: 10.1046/j.1524-4725.2003.29141.x.
Despite the widespread and quite successful use of various lasers and light sources to treat facial erythema, the literature contains little, if any, objective and quantitative improvement. In addition, very few studies specifically address rosacea-associated erythema.
To assess quantitatively the degree of improvement in patients with rosacea after intense pulsed light treatment. The three main parameters that were objectively measured were blood flow, telangiectasia, and erythema.
Four patients with rosacea-associated erythema and telangiectasia were treated five times at 3-week intervals with the Photoderm VL (Lumenis, Needham, MA). The 515-nm filter, a single pulse duration of 3 ms, and various fluences were used. Blood flow was measured by the scanning laser Doppler. Close-up photography ensured reproducibility and enabled quantification of telangiectasia and erythema by subsequent computer image analysis. Measurements were taken at baseline and at 1 month after the last treatment.
The scanning laser Doppler demonstrated a 30% decrease in blood flow (P<0.05). A 29% decrease in actual area of the cheek occupied by telangiectasia was noted (P<0.05). A 21% decrease in the intensity of erythema was noted (P<0.05).
As demonstrated by truly objective and quantitative means, intense pulsed light is effective for reducing rosacea-associated blood flow, telangiectasia, and erythema.
尽管各种激光和光源在治疗面部红斑方面得到广泛且颇为成功的应用,但文献中几乎没有客观定量的改善情况报道。此外,极少有研究专门针对酒渣鼻相关的红斑。
定量评估强脉冲光治疗后酒渣鼻患者的改善程度。客观测量的三个主要参数为血流、毛细血管扩张和红斑。
4例伴有红斑和毛细血管扩张的酒渣鼻患者,使用科医人公司(位于马萨诸塞州尼德姆)的Photoderm VL,每隔3周治疗5次。采用515纳米滤光片、单脉冲持续时间3毫秒及不同能量密度。通过扫描激光多普勒测量血流。特写摄影确保了可重复性,并能通过后续计算机图像分析对毛细血管扩张和红斑进行定量。在基线及最后一次治疗后1个月进行测量。
扫描激光多普勒显示血流减少30%(P<0.05)。毛细血管扩张占据的面颊实际面积减少29%(P<0.05)。红斑强度降低21%(P<0.05)。
通过真正客观定量的方法证明,强脉冲光在减少酒渣鼻相关的血流、毛细血管扩张和红斑方面有效。