Suppr超能文献

强脉冲光治疗后酒渣鼻相关红斑的客观定量改善

Objective and quantitative improvement of rosacea-associated erythema after intense pulsed light treatment.

作者信息

Mark Kenneth A, Sparacio Rose Marie, Voigt Audra, Marenus Kenneth, Sarnoff Deborah S

机构信息

Department of Dermatology, New York University School of Medicine, New York, USA.

出版信息

Dermatol Surg. 2003 Jun;29(6):600-4. doi: 10.1046/j.1524-4725.2003.29141.x.

Abstract

BACKGROUND

Despite the widespread and quite successful use of various lasers and light sources to treat facial erythema, the literature contains little, if any, objective and quantitative improvement. In addition, very few studies specifically address rosacea-associated erythema.

OBJECTIVE

To assess quantitatively the degree of improvement in patients with rosacea after intense pulsed light treatment. The three main parameters that were objectively measured were blood flow, telangiectasia, and erythema.

METHODS

Four patients with rosacea-associated erythema and telangiectasia were treated five times at 3-week intervals with the Photoderm VL (Lumenis, Needham, MA). The 515-nm filter, a single pulse duration of 3 ms, and various fluences were used. Blood flow was measured by the scanning laser Doppler. Close-up photography ensured reproducibility and enabled quantification of telangiectasia and erythema by subsequent computer image analysis. Measurements were taken at baseline and at 1 month after the last treatment.

RESULTS

The scanning laser Doppler demonstrated a 30% decrease in blood flow (P<0.05). A 29% decrease in actual area of the cheek occupied by telangiectasia was noted (P<0.05). A 21% decrease in the intensity of erythema was noted (P<0.05).

CONCLUSION

As demonstrated by truly objective and quantitative means, intense pulsed light is effective for reducing rosacea-associated blood flow, telangiectasia, and erythema.

摘要

背景

尽管各种激光和光源在治疗面部红斑方面得到广泛且颇为成功的应用,但文献中几乎没有客观定量的改善情况报道。此外,极少有研究专门针对酒渣鼻相关的红斑。

目的

定量评估强脉冲光治疗后酒渣鼻患者的改善程度。客观测量的三个主要参数为血流、毛细血管扩张和红斑。

方法

4例伴有红斑和毛细血管扩张的酒渣鼻患者,使用科医人公司(位于马萨诸塞州尼德姆)的Photoderm VL,每隔3周治疗5次。采用515纳米滤光片、单脉冲持续时间3毫秒及不同能量密度。通过扫描激光多普勒测量血流。特写摄影确保了可重复性,并能通过后续计算机图像分析对毛细血管扩张和红斑进行定量。在基线及最后一次治疗后1个月进行测量。

结果

扫描激光多普勒显示血流减少30%(P<0.05)。毛细血管扩张占据的面颊实际面积减少29%(P<0.05)。红斑强度降低21%(P<0.05)。

结论

通过真正客观定量的方法证明,强脉冲光在减少酒渣鼻相关的血流、毛细血管扩张和红斑方面有效。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验