Papageorgiou P, Clayton W, Norwood S, Chopra S, Rustin M
Department of Dermatology, Royal Free Hampstead NHS Trust, London NW3 2QG, UK.
Br J Dermatol. 2008 Sep;159(3):628-32. doi: 10.1111/j.1365-2133.2008.08702.x. Epub 2008 Jun 28.
Rosacea is a common skin condition but the treatments currently available are not satisfactory.
To assess the efficacy of intense pulsed light (IPL) for treatment of stage I rosacea (flushing, erythema and telangiectasia).
Thirty-four patients were treated, 25 women and nine men, mean age 47 years. The treatment employed was IPL 515-1200 nm, with a 560 nm cut-off filter. The fluence range was 24-32 J cm(-2). Four treatments were administered on the face at 3-week intervals. Erythema values were measured at baseline and at the end of the treatment period on the cheeks and chin. Digital photographs were assessed by a consultant dermatologist on a 10-point visual analogue scale (VAS). Patients' assessments were also made using a 10-point VAS. Outcome measures were repeated 6 months after treatment.
After four treatments the mean reduction of the erythema values was 39% on the cheeks (P < 0.001) and 22% on the chin (P < 0.001). This was confirmed by photographic assessment where erythema improved by 46% and telangiectasia by 55% (P < 0.001). The severity of rosacea was reduced on average by 3.5 points on the 10-point VAS. Patients' and physicians' assessments of the overall improvement of rosacea were similar: more than 50% improvement was noticed in 73% and 83% of patients, respectively (P < 0.001). The results were sustained at 6 months. Side-effects were minimal and self-limiting.
IPL significantly reduces erythema and telangiectasia of rosacea and this is sustained for at least 6 months.
酒渣鼻是一种常见的皮肤疾病，但目前可用的治疗方法并不令人满意。
评估强脉冲光（IPL）治疗I期酒渣鼻（潮红、红斑和毛细血管扩张）的疗效。
对34例患者进行治疗，其中女性25例，男性9例，平均年龄47岁。采用515 - 1200nm的IPL进行治疗，使用560nm截止滤光片。能量密度范围为24 - 32J/cm²。在面部进行4次治疗，间隔3周。在基线时以及治疗期结束时测量脸颊和下巴处的红斑值。由皮肤科顾问医生使用10分视觉模拟量表（VAS）对数码照片进行评估。患者也使用10分VAS进行评估。治疗后6个月重复进行结果测量。
经过4次治疗后，脸颊处红斑值平均降低39%（P < 0.001），下巴处降低22%（P < 0.001）。这通过照片评估得到证实，其中红斑改善了46%，毛细血管扩张改善了55%（P < 0.001）。在10分VAS上，酒渣鼻的严重程度平均降低了3.5分。患者和医生对酒渣鼻总体改善情况的评估相似：分别有73%和83%的患者改善超过50%（P < 0.001）。结果在6个月时仍持续存在。副作用轻微且为自限性。
强脉冲光显著降低酒渣鼻的红斑和毛细血管扩张，且这种效果至少持续6个月。
