地西泮和丁溴东莨菪碱对人对促胰液素和缩胆囊素-促胰酶素反应的影响。
Effect of diazepam and hyoscine butylbromide on response to secretin and cholecystokinin-pancreozymin in man.
作者信息
Saunders J H, Masoero G, Wormsley K G
出版信息
Gut. 1976 May;17(5):351-3. doi: 10.1136/gut.17.5.351.
Abstract
Ten subjects received secretin and cholecystokinin or, in duplicate tests, the two hormones together with either diazepam or diazepam plus hyoscine butylbromide in order to determine whether these drugs, which are often used during retrograde endoscopic cannulation of the pancreatic duct, affect pancreatic and biliary secretion in response to the hormones. Diazepam with hyoscine butylbromide reduced the secretion of trypsin into the duodenum and delayed the appearance of both trypsin and bilirubin in duodenal aspirate. These effects must be taken into account when interpreting pancreatic and biliary responses measured during direct cannulation of the pancreatic duct.
摘要
十名受试者接受了促胰液素和胆囊收缩素，或者在重复试验中，接受这两种激素与地西泮或地西泮加丁溴东莨菪碱的组合，以确定这些在逆行内镜胰管插管过程中常用的药物是否会影响胰腺和胆汁对激素的分泌。地西泮与丁溴东莨菪碱减少了胰蛋白酶向十二指肠的分泌，并延迟了十二指肠抽吸物中胰蛋白酶和胆红素的出现。在解释胰管直接插管过程中测得的胰腺和胆汁反应时，必须考虑这些影响。
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