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1
Effect of diazepam and hyoscine butylbromide on response to secretin and cholecystokinin-pancreozymin in man.地西泮和丁溴东莨菪碱对人对促胰液素和缩胆囊素-促胰酶素反应的影响。
Gut. 1976 May;17(5):351-3. doi: 10.1136/gut.17.5.351.
2
The effect of hyoscine-N-butylbromide on exocrine pancreatic secretion.丁溴东莨菪碱对胰腺外分泌的影响。
S Afr Med J. 1977 Jul 2;52(1):17-9.
3
Secretion of pancreatic enzymes. 3. Response of patients with cirrhosis to secretin and pancreozymin.胰腺酶的分泌。3. 肝硬化患者对促胰液素和胰酶泌素的反应。
Am J Dig Dis. 1967 Mar;12(3):303-9. doi: 10.1007/BF02233649.
4
Profiles of pure pancreatic secretions obtained by direct pancreatic duct cannulation in normal healthy human subjects.通过对正常健康人体受试者进行胰管直接插管获取的纯胰液分泌情况。
Gastroenterology. 1978 Dec;75(6):1083-9.
5
[Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration (author's transl)].生长抑素对人注射促胰液素和缩胆囊素-促胰酶素后引起的胰液和酶分泌及胆囊收缩的抑制作用（作者译）
Dtsch Med Wochenschr. 1975 May 16;100(20):1135-8.
6
Response of the rat exocrine pancreas to secretin and cholecystokinin-pancreozymin.大鼠外分泌胰腺对促胰液素和缩胆囊素-促胰酶素的反应。
Can J Physiol Pharmacol. 1973 May;51(5):383-9. doi: 10.1139/y73-057.
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Pancreatic secretion stimulated by a gastrin-like pentapeptide.一种胃泌素样五肽刺激胰腺分泌。
Am J Dig Dis. 1968 Sep;13(9):767-74. doi: 10.1007/BF02233091.
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[Pancreatic secretion in man after stimulation with cholecystokinin-pancreozymin, secretin and bile. Methods and normal ranges (author's transl)].[人经胆囊收缩素-促胰酶素、促胰液素和胆汁刺激后的胰腺分泌。方法及正常范围（作者译）]
Klin Wochenschr. 1973 Sep 15;51(18):915-20. doi: 10.1007/BF01468066.
9
Comparison of juice obtained during duodenal aspiration and cannulation of the main pancreatic duct after stimulation with exogenous secretin in man.人体经外源性促胰液素刺激后十二指肠抽吸液与主胰管插管获取液的比较。
Scand J Gastroenterol. 1978;13(4):453-8. doi: 10.3109/00365527809181921.
10
A comparison of the response to secretin, pancreozymin and a combination of these hormones, in man.人体对促胰液素、胰酶泌素以及这两种激素联合使用的反应比较。
Scand J Gastroenterol. 1969;4(5):411-7.

引用本文的文献

1
Endoscopy-based pancreatic function tests.基于内镜的胰腺功能测试。
Curr Gastroenterol Rep. 2006 Apr;8(2):127-31. doi: 10.1007/s11894-006-0008-6.
2
Direct measurement of pancreatic enzymes: a comparison of secretagogues.胰腺酶的直接测量：促分泌剂的比较
Dig Dis Sci. 2002 Oct;47(10):2211-6. doi: 10.1023/a:1020127025489.
3
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function.导管内胰泌素试验在评估胰腺外分泌功能方面与十二指肠胰泌素试验同样有用。
Dig Dis Sci. 1997 Mar;42(3):492-6. doi: 10.1023/a:1018878505670.
4
Metabolism of 125I-labelled trypsin in man: evidence of recirculation.125I标记的胰蛋白酶在人体中的代谢：再循环的证据。
Gut. 1980 Jul;21(7):580-6. doi: 10.1136/gut.21.7.580.
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Exocrine pancreatic function tests.外分泌胰腺功能测试
Gut. 1982 Sep;23(9):777-98. doi: 10.1136/gut.23.9.777.
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Lactoferrin and albumin in human pancreatic juice: a valuable test for diagnosis of pancreatic diseases.人胰液中的乳铁蛋白和白蛋白：一种用于诊断胰腺疾病的有价值检测方法。
Dig Dis Sci. 1980 Mar;25(3):173-8. doi: 10.1007/BF01308135.
7
Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 3. Tests on pure pancreatic juice.慢性胰腺疾病诊断中的实验室检查。第3部分。纯胰液检查。
Int J Pancreatol. 1987 Oct-Dec;2(5-6):291-304. doi: 10.1007/BF02788429.
8
Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 2. Tests of pancreatic secretion.慢性胰腺疾病诊断中的实验室检查。第2部分。胰腺分泌功能检查。
Int J Pancreatol. 1987 Aug;2(4):211-21. doi: 10.1007/BF02788399.
9
Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 1. Secretagogues used in tests of pancreatic secretion.慢性胰腺疾病诊断中的实验室检查。第1部分。胰腺分泌功能检查中使用的促分泌剂。
Int J Pancreatol. 1987 Jun;2(3):137-48. doi: 10.1007/BF02788212.
10
Modifications of pure human pancreatic juice induced by chronic alcohol consumption.
Dig Dis Sci. 1979 Dec;24(12):897-905. doi: 10.1007/BF01311942.

本文引用的文献

1
OBSERVATION ON PANCREATIC FUNCTION IN EIGHT PATIENTS WITH CONTROLLED PANCREATIC FISTULAS: INCLUDING A REVIEW OF THE LITERATURE.八例胰瘘得到控制的患者的胰腺功能观察：包括文献综述
Ann Surg. 1964 Dec;160(6):937-49. doi: 10.1097/00000658-196412000-00001.
2
Inhibitory effect of new anticholinergics on the basal and secretin-stimulated pancreatic secretion in patients with and without pancreatic disease: therapeutic and theoretic implications.新型抗胆碱能药物对有无胰腺疾病患者基础及促胰液素刺激的胰腺分泌的抑制作用：治疗及理论意义
Am J Dig Dis. 1960 Jul;5:639-54. doi: 10.1007/BF02290198.
3
Effect of propantheline bromide and pipenzolate bromide upon exocrine pancreatic secretion.溴丙胺太林和溴哌喷酯对胰腺外分泌的影响。
Gastroenterology. 1968 Aug;55(2):199-203.
4
Proceedings: Biochemical studies on pure pancreatic juice obtained by duodenoscopic cannulation of the pancreatic duct in conscious patients.
Gut. 1974 Oct;15(10):838.
5
Anticholinergic drug action on pancreatic exocrine outflow in man and dog.抗胆碱能药物对人和犬胰腺外分泌流出的作用。
Am J Dig Dis. 1968 Jul;13(7):608-14. doi: 10.1007/BF02232967.
6
Pancreatic secretion of total protein and of three hydrolases collected in healthy subjects via duodenoscopic cannulation. Effects of secretin, pancreozymin, and caerulein.通过十二指肠镜插管收集健康受试者的胰腺总蛋白分泌量以及三种水解酶的分泌量。促胰液素、胰酶泌素和蛙皮素的作用。
Gastroenterology. 1975 Aug;69(2):374-9.

地西泮和丁溴东莨菪碱对人对促胰液素和缩胆囊素-促胰酶素反应的影响。

Effect of diazepam and hyoscine butylbromide on response to secretin and cholecystokinin-pancreozymin in man.

作者信息

Saunders J H, Masoero G, Wormsley K G

出版信息

Gut. 1976 May;17(5):351-3. doi: 10.1136/gut.17.5.351.

DOI:10.1136/gut.17.5.351
PMID:1278718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411135/
Abstract

Ten subjects received secretin and cholecystokinin or, in duplicate tests, the two hormones together with either diazepam or diazepam plus hyoscine butylbromide in order to determine whether these drugs, which are often used during retrograde endoscopic cannulation of the pancreatic duct, affect pancreatic and biliary secretion in response to the hormones. Diazepam with hyoscine butylbromide reduced the secretion of trypsin into the duodenum and delayed the appearance of both trypsin and bilirubin in duodenal aspirate. These effects must be taken into account when interpreting pancreatic and biliary responses measured during direct cannulation of the pancreatic duct.

摘要

十名受试者接受了促胰液素和胆囊收缩素，或者在重复试验中，接受这两种激素与地西泮或地西泮加丁溴东莨菪碱的组合，以确定这些在逆行内镜胰管插管过程中常用的药物是否会影响胰腺和胆汁对激素的分泌。地西泮与丁溴东莨菪碱减少了胰蛋白酶向十二指肠的分泌，并延迟了十二指肠抽吸物中胰蛋白酶和胆红素的出现。在解释胰管直接插管过程中测得的胰腺和胆汁反应时，必须考虑这些影响。