Yang Jui-Yung, Chuang Shiow-Shuh, Yang Wen-Guei, Tsay Pei-Kwei
Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
Chang Gung Med J. 2003 Mar;26(3):153-9.
This preliminary investigation attempted to determine the effectiveness of egg membranes as a new biological dressing to promote infection-free healing and provide pain relief over split-thickness skin graft (STSG) donor sites.
Eighteen patients, with 28 STSG donor sites who were admitted to the LinKou Burn Center from August 1997 to July 1999, were selected for this trial. The bilateral thighs were the main donor sites for STSG. To compare different dressings, Surgilon, B.G.C. (beta-glucan collagen), and Biobrane were applied to the same donor sites, and epithelialization, pain relief, fluid accumulation, hematoma formation, and the occurrence of rejection or infection were monitored post-application.
The average wound healing time with egg membrane application was 11.64 +/- 1.29 (range, 10 to 13) days. Meanwhile, the average wound healing times for B.G.C. (6 patients) and Biobrane (6 patients) were 14.5 +/- 0.84 and 14.0 +/- 0.63 days, respectively. Finally, Surgilon (16 patients) had the longest healing time, at 16 +/- 1.41 days. On average, complete pain relief was achieved by 7.3 +/- 0.70 days for egg membrane application, while for B.G.C., Biobrane, and Surgilon, complete pain relief occurred by 7.0 +/- 0.89, 6.0 +/- 0.63, and 10.0 +/- 0.37 days, respectively. Finally, no infection or rejection developed during healing.
From this preliminary study, egg membrane may be an ideal STSG donor site dressing, as it possesses properties of pain relief, wound protection, promotion of healing, and low cost. However, the limited unit size must be overcome, and its clinical application for burn wounds should be studied.
本初步研究旨在确定卵膜作为一种新型生物敷料，在促进中厚皮片（STSG）供皮区无感染愈合及缓解疼痛方面的有效性。
选取1997年8月至1999年7月入住林口烧伤中心的18例患者的28个STSG供皮区进行本试验。双侧大腿是STSG的主要供皮区。为比较不同敷料，将Surgilon、B.G.C.（β-葡聚糖胶原蛋白）和生物膜应用于同一供皮区，并在应用后监测上皮化、疼痛缓解、积液、血肿形成以及排斥或感染的发生情况。
应用卵膜的伤口平均愈合时间为11.64±1.29（范围10至13）天。同时，B.G.C.（6例患者）和生物膜（6例患者）的伤口平均愈合时间分别为14.5±0.84天和14.0±0.63天。最后，Surgilon（16例患者）的愈合时间最长，为16±1.41天。平均而言，应用卵膜7.3±0.70天实现完全疼痛缓解，而B.G.C.、生物膜和Surgilon分别在7.0±0.89天、6.0±0.63天和10.0±0.37天实现完全疼痛缓解。最后，愈合过程中未发生感染或排斥反应。
从本初步研究来看，卵膜可能是理想的STSG供皮区敷料，因为它具有缓解疼痛、保护伤口、促进愈合和成本低的特性。然而，必须克服其单位尺寸有限的问题，并且应研究其在烧伤创面的临床应用。
