Diekema Daniel J, Andrews Janet I, Huynh Holly, Rhomberg Paul R, Doktor Stella R, Beyer Jill, Shortridge Virginia D, Flamm Robert K, Jones Ronald N, Pfaller Michael A
Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA.
J Clin Microbiol. 2003 Jun;41(6):2659-61. doi: 10.1128/JCM.41.6.2659-2661.2003.
Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.
对122株B族链球菌（GBS）新生儿血流分离株进行脉冲场凝胶电泳（PFGE），以进一步研究大环内酯类耐药性与V型GBS（GBS-V）之间的关系。超过三分之一（35%）的大环内酯类耐药GBS属于GBS-V的单一PFGE亚型，这也是先前疾病控制和预防中心监测研究中发现的最常见的GBS-V亚型。Erm甲基化酶（ermA和ermB）是检测到的最常见耐药机制，在20株大环内酯类耐药GBS中有12株存在该机制。
