蓝藻生物钟的超微时间机器遗传学。
The itty-bitty time machine genetics of the cyanobacterial circadian clock.
机构信息
Biology Department, St. Ambrose University, Davenport, Iowa, USA.
出版信息
Adv Genet. 2011;74:13-53. doi: 10.1016/B978-0-12-387690-4.00002-7.
Abstract
The cyanobacterium Synechococcus elongatus PCC 7942 has been used as the prokaryotic model system for the study of circadian rhythms for the past two decades. Its genetic malleability has been instrumental in the discovery of key input, oscillator, and output components and has also provided monumental insights into the mechanism by which proteins function to maintain and dictate 24-h time. In addition, basic research into the prokaryotic system has led to interesting advances in eukaryotic circadian mechanisms. Undoubtedly, continued genetic and mutational analyses of this single-celled cyanobacterium will aid in teasing out the intricacies of the Kai-based circadian clock to advance our understanding of this system as well as other more "complex" systems.
摘要
过去二十年，聚球藻 PCC 7942 一直被用作研究生物钟的原核模式生物。其遗传的可操作性对于发现关键的输入、振荡器和输出组件起到了重要作用，同时也深入揭示了蛋白质如何发挥作用以维持和指示 24 小时时间的机制。此外，对原核系统的基础研究导致了真核生物钟机制的有趣进展。毫无疑问，对这种单细胞蓝藻的持续遗传和突变分析将有助于梳理基于 Kai 的生物钟的复杂性，从而增进我们对该系统以及其他更“复杂”系统的理解。
相似文献
1
The itty-bitty time machine genetics of the cyanobacterial circadian clock.蓝藻生物钟的超微时间机器遗传学。
Adv Genet. 2011;74:13-53. doi: 10.1016/B978-0-12-387690-4.00002-7.
2
Minimal tool set for a prokaryotic circadian clock.原核生物钟的最小工具集。
BMC Evol Biol. 2017 Jul 21;17(1):169. doi: 10.1186/s12862-017-0999-7.
3
Circadian Rhythms in Cyanobacteria.蓝藻中的昼夜节律
Microbiol Mol Biol Rev. 2015 Dec;79(4):373-85. doi: 10.1128/MMBR.00036-15.
4
Stability of the Synechococcus elongatus PCC 7942 circadian clock under directed anti-phase expression of the kai genes.集胞藻PCC 7942生物钟在kai基因定向反相表达下的稳定性
Microbiology (Reading). 2005 Aug;151(Pt 8):2605-2613. doi: 10.1099/mic.0.28030-0.
5
Circadian timing mechanism in the prokaryotic clock system of cyanobacteria.蓝细菌原核生物钟系统中的昼夜节律计时机制。
J Biol Rhythms. 2004 Oct;19(5):436-44. doi: 10.1177/0748730404269060.
6
A cyanobacterial circadian timing mechanism.一种蓝藻生物钟机制。
Annu Rev Genet. 2003;37:513-43. doi: 10.1146/annurev.genet.37.110801.142716.
7
No promoter left behind: global circadian gene expression in cyanobacteria.一个启动子都不落下：蓝细菌中的全球昼夜节律基因表达
J Biol Rhythms. 2006 Dec;21(6):419-31. doi: 10.1177/0748730406294418.
8
Diversity of KaiC-based timing systems in marine Cyanobacteria.海洋蓝细菌中基于KaiC的计时系统的多样性。
Mar Genomics. 2014 Apr;14:3-16. doi: 10.1016/j.margen.2013.12.006. Epub 2014 Jan 3.
9
Global gene repression by KaiC as a master process of prokaryotic circadian system.作为原核生物钟系统的主要过程，KaiC介导的全基因组基因表达抑制
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):881-5. doi: 10.1073/pnas.0307411100. Epub 2004 Jan 6.
10
The current state and problems of circadian clock studies in cyanobacteria.蓝藻生物钟研究的现状与问题
Plant Cell Physiol. 2000 Sep;41(9):1013-20. doi: 10.1093/pcp/pcd024.
引用本文的文献
1
Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping.研究人类微生物组：对生物钟的基本原理、起源和进化的理解进展。
Int J Mol Sci. 2023 Nov 10;24(22):16169. doi: 10.3390/ijms242216169.
2
Thiol redox switches regulate the oligomeric state of cyanobacterial Rre1, RpaA and RpaB response regulators.巯基氧化还原开关调节蓝藻 Rre1、RpaA 和 RpaB 反应调节剂的寡聚状态。
FEBS Lett. 2022 Jun;596(12):1533-1543. doi: 10.1002/1873-3468.14340. Epub 2022 Apr 11.
3
Expression and Purification of Cyanobacterial Circadian Clock Protein KaiC and Determination of Its Auto-phosphatase Activity.蓝藻生物钟蛋白KaiC的表达、纯化及其自磷酸酶活性的测定
Bio Protoc. 2017 Feb 20;7(4):e2140. doi: 10.21769/BioProtoc.2140.
4
Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway.大麻二酚通过靶向WNT/β-连环蛋白信号通路在强迫症中的潜在作用。
Mol Psychiatry. 2022 Jan;27(1):230-248. doi: 10.1038/s41380-021-01086-1. Epub 2021 Apr 9.
5
The influence of circadian rhythms and aerobic glycolysis in autism spectrum disorder.昼夜节律和有氧糖酵解对自闭症谱系障碍的影响。
Transl Psychiatry. 2020 Nov 16;10(1):400. doi: 10.1038/s41398-020-01086-9.
6
Circadian clock-controlled gene expression in co-cultured, mat-forming cyanobacteria.共培养形成藻席的蓝细菌中生物钟控制的基因表达。
Sci Rep. 2020 Aug 24;10(1):14095. doi: 10.1038/s41598-020-69294-3.
7
Chemical Perturbation of Chloroplast-Related Processes Affects Circadian Rhythms of Gene Expression in : Salicylic Acid Application Can Entrain the Clock.叶绿体相关过程的化学扰动影响基因表达的昼夜节律：水杨酸处理可重置生物钟。
Front Physiol. 2020 Jun 18;11:429. doi: 10.3389/fphys.2020.00429. eCollection 2020.
8
Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson's Disease.昼夜节律、神经炎症和氧化应激在帕金森病中的故事。
Cells. 2020 Jan 28;9(2):314. doi: 10.3390/cells9020314.
9
Circadian Rhythms in Exudative Age-Related Macular Degeneration: The Key Role of the Canonical WNT/β-Catenin Pathway.渗出型年龄相关性黄斑变性的昼夜节律：经典 WNT/β-连环蛋白通路的关键作用。
Int J Mol Sci. 2020 Jan 27;21(3):820. doi: 10.3390/ijms21030820.
10
Genome-wide fitness assessment during diurnal growth reveals an expanded role of the cyanobacterial circadian clock protein KaiA.在昼夜生长过程中的全基因组适应性评估揭示了蓝细菌生物钟蛋白 KaiA 的扩展作用。
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7174-E7183. doi: 10.1073/pnas.1802940115. Epub 2018 Jul 10.
本文引用的文献
1
Circadian rhythms persist without transcription in a eukaryote.真核生物中，转录缺失时昼夜节律仍能持续。
Nature. 2011 Jan 27;469(7331):554-8. doi: 10.1038/nature09654.
2
Circadian clocks in human red blood cells.人类红细胞中的生物钟。
Nature. 2011 Jan 27;469(7331):498-503. doi: 10.1038/nature09702.
3
Synchronization of circadian oscillation of phosphorylation level of KaiC in vitro.体外条件下 KaiC 磷酸化水平的昼夜节律振荡的同步化。
Biophys J. 2010 Jun 2;98(11):2469-77. doi: 10.1016/j.bpj.2010.02.036.
4
Circadian gating of the cell cycle revealed in single cyanobacterial cells.单细胞水平揭示细胞周期的昼夜节律调控。
Science. 2010 Mar 19;327(5972):1522-6. doi: 10.1126/science.1181759.
5
The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor.蓝藻生物钟振荡器的 KaiA 蛋白受氧化还原活性辅因子调节。
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5804-9. doi: 10.1073/pnas.0910141107. Epub 2010 Mar 15.
6
Elevated ATPase activity of KaiC applies a circadian checkpoint on cell division in Synechococcus elongatus.KaiC 的 ATP 酶活性对集胞藻细胞分裂施加了一个昼夜节律检查点。
Cell. 2010 Feb 19;140(4):529-39. doi: 10.1016/j.cell.2009.12.042.
7
Three major output pathways from the KaiABC-based oscillator cooperate to generate robust circadian kaiBC expression in cyanobacteria.基于 KaiABC 的振荡器的三个主要输出途径协同作用，以在蓝藻中产生稳健的生物钟 kaiBC 表达。
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3263-8. doi: 10.1073/pnas.0909924107. Epub 2010 Jan 28.
8
In vitro regulation of circadian phosphorylation rhythm of cyanobacterial clock protein KaiC by KaiA and KaiB.在体外通过 KaiA 和 KaiB 对蓝藻生物钟蛋白 KaiC 的昼夜磷酸化节律进行调节。
FEBS Lett. 2010 Mar 5;584(5):898-902. doi: 10.1016/j.febslet.2010.01.016. Epub 2010 Jan 16.
9
Oscillations in supercoiling drive circadian gene expression in cyanobacteria.超螺旋的波动驱动蓝细菌的生物钟基因表达。
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22564-8. doi: 10.1073/pnas.0912673106. Epub 2009 Dec 14.
10
Structures of KaiC circadian clock mutant proteins: a new phosphorylation site at T426 and mechanisms of kinase, ATPase and phosphatase.KaiC 生物钟突变蛋白结构：T426 上新的磷酸化位点及激酶、ATP 酶和磷酸酶的作用机制。
PLoS One. 2009 Nov 26;4(11):e7529. doi: 10.1371/journal.pone.0007529.
Zotero 插件