Saladino Raffaele, Crestini Claudia, Neri Veronica, Brucato John R, Colangeli Luigi, Ciciriello Fabiana, Di Mauro Ernesto, Costanzo Giovanna
Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy.
Chembiochem. 2005 Aug;6(8):1368-74. doi: 10.1002/cbic.200500035.
We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
我们展示了在橄榄石的宇宙尘埃类似物（CDAs）存在下，由甲酰胺一步合成大量嘧啶（包括胞嘧啶和尿嘧啶）和嘌呤的前所未有的方法。由于信息大分子起源中的主要问题是其前体的不稳定性，我们还研究了CDAs对甲酰胺中寡核苷酸固有不稳定性的稳定作用。
